The Regulation of Intracellualr Calcium

  • Ernesto Carafoli
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 151)


The regulation of Ca2+ in cells is a complex process, based on the concerted operation of several transport systems located in the plasma membrane and in the intracellular organelles, and on the reversible complexation of Ca2+ by soluble cytosolic ligands. The plasma membrane contains a channel for the downhill penetration of Ca2+ into the cell from the environment. In excitable cells, the channel is controlled by electrical currents. It also contains 2 systems which are responsible for the pumping of Ca2+ out of the cell, a specific ATPase, and a Na+/Ca2+ exchanger. Inside cells, Ca2+ is transported reversibly by mitochondria and sarco(endo) plasmic reticulum. The former organelle accumulates Ca2+ electrophoretically, and releases it through a separate pathway. The latter accumulates Ca2+ through a specific ATPase, and releases it through a route which has not yet been identified. The reversible complexation of Ca2+ in the cytosol involves the participation of low Mr ligands (e.g., phosphate, adenine nucleotides) and of proteins. Many Ca2+-binding proteins have been described in different cells, e.g., troponin-C, parvalbumin.


Sarcoplasmic Reticulum Excitable Cell Intracellular Organelle Plasmic Reticulum Acidic Phospholipid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Ernesto Carafoli
    • 1
  1. 1.Laboratory of BiochemistrySwiss Federal Institute of Technology (ETH)ZürichSwitzerland

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