Relationship between Plasma Phosphate and Renal Handling of Phosphate: Studies with Low Phosphate Diet and Nicotinamide

  • Aviad Haramati
  • Franklyn G. Knox
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 151)


Acute intravenous infusions of phosphate have been used to study the relationship between plasma phosphate concentration and renal phosphate excretion (1 – 10). Animals maintained on a normal intake of phosphorus (0.8 – 1.2%) respond to acute phosphate infusions with phosphate excretions ranging from 60 – 90% of the filtered load (5, 7, 9). The high phosphate excretions are not only the result of increases in tubular load exceeding the reabsorptive capacity, but recent studies indicate that at high plasma phosphate concentrations (induced by prolonged intravenous phosphate infusions) the maximal transport rate actually declines (3, 4, 6, 9–11).


Nicotinamide Adenine Dinucleotide Phosphate Excretion Renal Phosphate Phosphate Reabsorption Phosphate Diet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Pitts, R. F. and R. S. Alexander. The renal reabsorptive mechanism for inorganic phosphate in normal and acidotic dogs. Am. J. Physiol. 142:648–662, 1944.Google Scholar
  2. 2.
    Hogben, C. A. M. and J. L. Bollman. Renal reabsorption of phosphate: Normal and thyroparathyroidectomized dog. Am. J. Physiol. 164:670–681, 1951.PubMedGoogle Scholar
  3. 3.
    Frick, A. Reabsorption of inorganic phosphate in the rat kidney I. Saturation of transport mechanism. II. Suppression of fractional phosphate reabsorption due to expansion of extracellular fluid volume. Pfluegers Arch. 304:351–364, 1968.CrossRefGoogle Scholar
  4. 4.
    LeGrimellec, C., N. Roinel and F. Morel. Simultaneous Mg, Ca, P. K. Na and Cl analysis in rat tubular fluid. IV. During acute phosphate plasma loading. Pfluegers Arch. 346:189–204, 1974.CrossRefGoogle Scholar
  5. 5.
    Boudry, J. F., U. Troehler, M. Touabi, H. Fleisch and J.-P. Bonjour. Secretion of inorganic phosphate in the rat nephron. Clin. Sci. Mol. Med. 48:475–489, 1975.Google Scholar
  6. 6.
    Engle, J. E. and T. H. Steele. Renal phosphate reabsorption in the rat: Effect of inhibitors. Kidney Int. 8:98–104, 1975.PubMedCrossRefGoogle Scholar
  7. 7.
    Troehler, U., J.-P. Bonjour and H. Fleisch. Inorganic phosphate homeostasis. Renal adaptation to the dietary intake in intact and thyroparathyroidectomized rats. J. Clin. Invest. 57:264–273, 1976.CrossRefGoogle Scholar
  8. 8.
    Steele, J. H. and H. F. DeLuca. Influence of dietary phosphorus on renal phosphate reabsorption in the parathyroidectomized rat. J. Clin. Invest. 57:867–874, 1976.PubMedCrossRefGoogle Scholar
  9. 9.
    Frick, A. and I. Durasin. Maximal reabsorptive capacity for inorganic phosphate (TMPi) in the absence of parathyroid hormone in the rat: Decrease of the TMPi during prolonged administration of phosphate and the role of calcium. Pfluegers Arch. 377:9–14, 1978.CrossRefGoogle Scholar
  10. 10.
    Oberleithner, H., R. Greger and F. Lang. Role of calcium in the decline of phosphate reabsorption during phosphate loading in acutely thyroparathyroidectomized rats. Pfluegers Arch. 374:249–254, 1978.CrossRefGoogle Scholar
  11. 11.
    Thompson, D. D. and H. H. Hiatt. Effects of phosphate loading and depletion on the renal excretion and reabsorption of inorganic phosphate. J. Clin. Invest. 36:566–572, 1957.PubMedCrossRefGoogle Scholar
  12. 12.
    Lang, G., H. Oberleithner, R. Greger and P. Deetjen. Factors involved in the altered phosphate reabsorption during phosphate loading in thyroparathyroidectomized rats. Adv. Exp. Med. Biol. 103:81–86, 1978.PubMedGoogle Scholar
  13. 13.
    Lang, F. Renal handling of calcium and phosphate. Klin. Wochenschr. 58:985–1003, 1980.PubMedCrossRefGoogle Scholar
  14. 14.
    Sutton, R. A. L. and J. H. Dirks. Renal handling of calcium, phosphate and magnesium. In: The Kidney, B. M. Brenner and F. C. Rector, eds., Saunders, Chapt. 12, pp. 551–618, 1981.Google Scholar
  15. 15.
    Kempson, S. A., G. Colon-Otero, S.-Y. L. Ou, S. T. Turner and T. P. Dousa. Possible role of nicotinamide adenine dinucleotide as an intracellular regulator of renal transport of phosphate in the rat. J. Clin. Invest. 67:1347–1360, 1981.PubMedCrossRefGoogle Scholar
  16. 16.
    Berndt, T. J., F. G. Knox and T. P. Dousa. Role of nicotine-adenine dinucleotide (NAD) in the Phosphaturic response to parathyroid hormone (PTH). Kidney Int. 19:108, 1981 (Abstract).Google Scholar
  17. 17.
    Dousa, T. P. and S. A. Kempson. Regulation of renal brush border membrane transport of phosphate. Min. & Elect. Metab. 1981 (in press).Google Scholar
  18. 18.
    Berndt, T. J., F. G. Knox, S. A. Kempson and T. P. Dousa. Nicotinamide adenine dinucleotide and renal response to parathyroid hormone. Endocrinology 108:2005–2007, 1981.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Aviad Haramati
    • 1
  • Franklyn G. Knox
    • 1
  1. 1.Department of Physiology & BiophysicsMayo Medical SchoolRochesterUSA

Personalised recommendations