Several years ago we intiated studies to clarify the problem of osteoporosis. On the basis of historical prospective, we reasoned that a disease of an organ is always attributable to inadequate regulation. That regulatory dysfunction may, in turn, be due to an overwhelmed regulatory mechanism, or to a faulty regulatory mechanism. Thus, inasmuch as osteoporosis is a disease of too little bone, we sought to characterize the regulation of bone volume.
KeywordsBone Formation Bone Resorption Conditioned Medium Bone Volume Coupling Factor
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