Adrenergic Blockade May Inhibit the Increase in Plasma 1,25-(OH)2-Vitamin D During Phosphate Deprivation in the Rat

  • Richard W. Gray
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 151)


Dietary phosphate deprivation in rats is accompanied by a 4 to 5 fold increase in the plasma concentration of 1,25-(OH)2-Vitamin D. This increase in plasma levels has recently been shown to be the result of increased renal synthesis of the hormone (1), and is not mediated by PTH or gonadal hormones (2–4). Earlier work by Tanaka and DeLuca (5) had suggested that this response might be mediated by hypophosphatemia per se, but recent experiments in rats have shown that hypophysectomy completely abolishes the response despite a comparable degree of hypophosphatemia in the phosphate-deprived hypophysectomized (hypox) animals (4). In addition, hypox rats retain their ability to increase plasma 1,25-(OH)2-D levels on a low Ca diet (4). Finally, replacement of phosphate-deprived hypox rats with either growth hormone or, independently, with thyroid hormone at least partially restores the ability of such animals to increase their plasma 1,25-(OH)2-D levels on a low phosphorus diet (6). These results would suggest that the low-phosphate stimulus to renal 1,25-(OH)2-D synthesis is, at least in part, hormonally mediated.


Growth Hormone Growth Hormone Secretion Adrenergic Blockade Dietary Phosphate Stimulate Growth Hormone Secretion 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Richard W. Gray
    • 1
  1. 1.Departments of Biochemistry and MedicineMedical College of WisconsinMilwaukeeUSA

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