Effects of Hypophosphatemia on Pulmonary Muscle Performance

  • Roque F. Planas
  • Reuben H. McBrayer
  • Peter A. Koen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 151)


Hypophosphatemia is a disorder often characterized by muscle weakness (1). In studies of cardiac performance in hypophos-phatemic patients, O’Connor (2) found that muscle contractility could be increased by phosphate repletion. Similar results were obtained by Fuller (3) in dogs fed a phosphorus deficient diet. Studies in adult patients (4,5,6) have shown that pulmonary muscle weakness may also be associated with hypophosphatemia, although the decrease in muscle force has not been measured. We therefore investigated the effects of a dietary — induced phosphorus depletion on pulmonary muscle force in dogs.


Phrenic Nerve Stimulation Mouth Pressure Diaphragmatic Fatigue Fatigue Stimulation Phosphorus Depletion 
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  1. 1.
    J. P. Knochel, The Pathophysiology and Clinical Characteristics of Severe Hypophosphatemia, Arch. Intern. Med., 137:203–220 (1977).PubMedCrossRefGoogle Scholar
  2. 2.
    L. R. O’Connor, W. S. Wheeler, and J. E. Bethune, Effect of Hypophosphatemia on Myocardial Performance in Man, N. Engl. J. Med., 297:901–903 (1977).PubMedCrossRefGoogle Scholar
  3. 3.
    T. J. Fuller, W. W. Nichols, B. J. Brenner and J. C. Peterson, Reversible Depression in Myocardial Performance in Dogs with Experimental Phosphorus Deficiency, J. Clin. Invest., 62:1194–1200 (1978)PubMedCrossRefGoogle Scholar
  4. 4.
    J. H. Newman, T. A. Neff, and P. Ziporin, Acute Respiratory Failure Associated with Hypophosphatemia, N. Engl. J. Med., 296:1101–1103 (1973).CrossRefGoogle Scholar
  5. 5.
    A. J. Furlan, M. Hanson, and A. Cooperman, Acute Areflexic Paralysis, Arch. Neurol. 32:706–707 (1975).PubMedCrossRefGoogle Scholar
  6. 6.
    J. R. Darsee, and D. O. Nutter, Reversible Severe Congestive Cardiomyopathy in Three Cases of Hypophosphatemia, Ann. Intern. Med., 89:867–870 (1978).PubMedGoogle Scholar
  7. 7.
    J. W. Coburn, and S. G. Massry, Changes in Serum and Urinary Calcium During Phosphate Depletion: Studies on Mechanisms, J. Clin. Invest., 49:1073–1087 (1970).PubMedCrossRefGoogle Scholar
  8. 8.
    J. Milic-Emili, J. Mead, J. M. Turner, and E. M. Glauser, Improved Technique for Estimating Pleural Pressure from Esophageal Balloons, J. Appl. Physiol., 19:207–211 (1964).PubMedGoogle Scholar
  9. 9.
    E. Agostoni, and Rahn, Abdominal and Thoracic Pressures at Different Lung Volumes, J. Appl. Physiol., 15:1087–1092 (1960).PubMedGoogle Scholar
  10. 10.
    M. Aubier, G. Farkas, A. DeTroyer, R. Mozes, and C. Roussos, Detection of Diaphragmatic Fatigue in Man by Phrenic Stimulation, J. Appl. Physiol., 50:538–544 (1981).PubMedGoogle Scholar
  11. 11.
    J. Moxham, A. J. R. Morris, S. G. Spiro, R. H. T. Edwards, and M. Green, Contractile Properties and Fatigue of the Diaphragm in Man, Thorax 36:164–168 (1981).PubMedCrossRefGoogle Scholar
  12. 12.
    W. H. Horl, W. Kreusser, A. Heidland, and E. Ritz, Abnormalities of Glycogen Metabolism in Cardiomyopathy of Phosphorus Depletion, in : S. G. Massry, E. Ritz, and H. Jahn, eds., New York: Plenum Press, 128:343–350 (1980).Google Scholar
  13. 13.
    R. H. T. Edwards, D. K. Hill, D. A. Jones, and P. A. Marton, Fatigue of Long Duration in Human Skeletal Muscle After Exercise, J. Physiol., (Lond), 272:769–778 (1977).Google Scholar
  14. 14.
    D. R. Rochester, N. S. Arora, S. K. Goldberg, J. McCormak, and D. Moore, Diaphragm Energy Metabolism in Acute Respiratory Failure (abstract), Physiologist, 22:107 (1979).Google Scholar
  15. 15.
    B. Bigland-Ritchie, D. A. Jones, and J. J. Woods, Excitation Frequency and Muscle Fatigue: Electrical Responses During Human Voluntary and Stimulated Contractions, Exper. Neur., 64:414–427 (1979)CrossRefGoogle Scholar
  16. 16.
    D. A. Jones, B. Bigland-Ritchie, and R. T. Edwards, Excitation Frequency and Muscle Fatigue: Mechanical Responses During Voluntary and Stimulated Contractions, Exper. Neur., 64:401–413 (1979).CrossRefGoogle Scholar
  17. 17.
    T. J. Fuller, N. W. Carter, C. Barcenas, and J. P. Knochel, Reversible Changes in the Muscle Cell in Experimental Phosphorus Deficiency, J. Clin. Invest., 57:1019–1024 (1976)PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Roque F. Planas
    • 1
  • Reuben H. McBrayer
    • 1
  • Peter A. Koen
    • 1
  1. 1.Departments of Internal Medicine and PhysiologyEastern Virginia Medical SchoolNorfolkUSA

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