Effects of Hypophosphatemia on Pulmonary Muscle Performance
Hypophosphatemia is a disorder often characterized by muscle weakness (1). In studies of cardiac performance in hypophos-phatemic patients, O’Connor (2) found that muscle contractility could be increased by phosphate repletion. Similar results were obtained by Fuller (3) in dogs fed a phosphorus deficient diet. Studies in adult patients (4,5,6) have shown that pulmonary muscle weakness may also be associated with hypophosphatemia, although the decrease in muscle force has not been measured. We therefore investigated the effects of a dietary — induced phosphorus depletion on pulmonary muscle force in dogs.
KeywordsPhrenic Nerve Stimulation Mouth Pressure Diaphragmatic Fatigue Fatigue Stimulation Phosphorus Depletion
Unable to display preview. Download preview PDF.
- 12.W. H. Horl, W. Kreusser, A. Heidland, and E. Ritz, Abnormalities of Glycogen Metabolism in Cardiomyopathy of Phosphorus Depletion, in : S. G. Massry, E. Ritz, and H. Jahn, eds., New York: Plenum Press, 128:343–350 (1980).Google Scholar
- 13.R. H. T. Edwards, D. K. Hill, D. A. Jones, and P. A. Marton, Fatigue of Long Duration in Human Skeletal Muscle After Exercise, J. Physiol., (Lond), 272:769–778 (1977).Google Scholar
- 14.D. R. Rochester, N. S. Arora, S. K. Goldberg, J. McCormak, and D. Moore, Diaphragm Energy Metabolism in Acute Respiratory Failure (abstract), Physiologist, 22:107 (1979).Google Scholar