Cardiac Function and Metabolism in Phosphorous Depleted Dogs — Effects of Hormonal Stimulation
Phosphorous depletion has recently been recognized as a cause of myocardial dysfunction in humans (1) and animals (2). O’Connor et al. (1) observed low stroke volume in acutely hypophosphatemic alcoholic patients. This abnormality returned to normal upon administration of phosphorous despite no change or even reduction of preload. Furthermore, in chronically phosphorous depleted patients, Darsee and Nutter (3) described a form of hypophosphatemic cardiomyopathy reversible upon phosphorous repletion. Finally, Fuller et al. (2) could reproduce the deleterious effect of phosphorous depletion on cardiac function in dogs with selective hypophosphatemia induced by dietary phosphorous depletion. The authors found a reversible depression of myocardial performance, i.e. of stroke volume, peak blood flow velocity and acceleration. These previous investigations were restricted to basal hemodynamic conditions and no information is available on the cardiac response to catecholamines.
KeywordsCalcium Transport Inotropic Response Phosphorous Depletion Depletion Period Phosphorous Deprivation
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