Hypophosphatemia and Glucose Intolerance
Part of the
Advances in Experimental Medicine and Biology
book series (AEMB, volume 151)
Hypophosphatemia is frequently observed in a variety of disease states including ketoacidosis, chronic alcoholism, malabsorption, severe burns, hyperparathyroidism, renal tubular defects, and re-feeding after starvation (1, 2). Since phosphate is a ubiquitous anion involved in such diverse functions as maintaining the structural integrity of the cell membrane, regulating a variety of intracellular enzymes, energy storage in the form of ATP, and regulating tissue delivery of oxygen through 2,3-DPG levels (2), it is not surprising that the clinical syndromes associated with phosphate depletion are equally diverse. Pathophysiologic disturbances associated with hypophosphatemia include hemolytic anemia, rhabdomyoly-sis, myopathy, impaired cardiac output, CNS abnormalities (encephalopathy, seizures), abnormal liver function tests, and platelet and leukocyte dysfunction (1, 2).
KeywordsObesity Cortisol Xylose Choline Galactose
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© Plenum Press, New York 1982