Hypophosphatemia and Glucose Intolerance
Part of the
Advances in Experimental Medicine and Biology
book series (AEMB, volume 151)
Hypophosphatemia is frequently observed in a variety of disease states including ketoacidosis, chronic alcoholism, malabsorption, severe burns, hyperparathyroidism, renal tubular defects, and re-feeding after starvation (1, 2). Since phosphate is a ubiquitous anion involved in such diverse functions as maintaining the structural integrity of the cell membrane, regulating a variety of intracellular enzymes, energy storage in the form of ATP, and regulating tissue delivery of oxygen through 2,3-DPG levels (2), it is not surprising that the clinical syndromes associated with phosphate depletion are equally diverse. Pathophysiologic disturbances associated with hypophosphatemia include hemolytic anemia, rhabdomyoly-sis, myopathy, impaired cardiac output, CNS abnormalities (encephalopathy, seizures), abnormal liver function tests, and platelet and leukocyte dysfunction (1, 2).
KeywordsInsulin Secretion Beta Cell Glucose Intolerance Plasma Glucose Concentration Glucose Infusion Rate
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Plenum Press, New York 1982