Hypophosphatemia and Osteoblast Function in Human Bone Disease
There is experimental evidence from both.in vitro and in vivo studies for three main effects of hypophosphatemia and phosphate depletion on bone. These are — an increase in osteoclastic resorption,1,3 a decrease in the rate of collagen synthesis by osteoblasts, 3,4 and defective bone mineralization.3,5 Studies in the intact rat using tetracycline labeling were reviewed by Ivey and colleagues at a previous Phosphate Workshop.6 This paper summarizes the relationship between osteoblast function studied by double tetracycline labeling7 and plasma inorganic phosphate (P) in various human metabolic bone diseases associated with chronic hypophosphatemia.
KeywordsPrimary Hyperparathyroidism Secondary Hyperparathyroidism Osteoblast Function Plasma Inorganic Phosphate Formation Velocity
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