Hypophosphatemia and Osteoblast Function in Human Bone Disease

  • A. M. Parfitt
  • A. R. Villanueva
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 151)


There is experimental evidence from both.in vitro and in vivo studies for three main effects of hypophosphatemia and phosphate depletion on bone. These are — an increase in osteoclastic resorption,1,3 a decrease in the rate of collagen synthesis by osteoblasts, 3,4 and defective bone mineralization.3,5 Studies in the intact rat using tetracycline labeling were reviewed by Ivey and colleagues at a previous Phosphate Workshop.6 This paper summarizes the relationship between osteoblast function studied by double tetracycline labeling7 and plasma inorganic phosphate (P) in various human metabolic bone diseases associated with chronic hypophosphatemia.


Primary Hyperparathyroidism Secondary Hyperparathyroidism Osteoblast Function Plasma Inorganic Phosphate Formation Velocity 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • A. M. Parfitt
    • 1
  • A. R. Villanueva
    • 1
  1. 1.Bone and Mineral Research LaboratoryHenry Ford HospitalDetroitUSA

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