Effects of Phosphate Depletion on the Myocardium
Indirect evidence suggests that cardiac function may be affected by phosphate depletion (PD). Coburn and Massry (l) found that glomerular filtration rate is reduced during phosphate depletion and it returned to normal with phosphate repletion. They suggested that this phenomenon may be related to alteration in cardiac function. O’Connor, Wheeler and Bethune (2) evaluated the effect of PD on cardiac function in seven patients. They found that stroke work was reduced but returned to normal after phosphate administration. Cardiac output, as well as left ventricular stroke volume, were decreased and correlated with the rise in pulmonary artery wedge pressures. The authors showed that with the correction of the hypophosphatemia, left ventricular stroke volume improved and pulmonary artery wedge pressure decreased. Their studies were the first direct demonstration that phosphate depletion may affect cardiac function in man.
KeywordsCreatine Phosphate Inorganic Phosphorus Creatine Phosphokinase Pulmonary Artery Wedge Pressure Left Ventricular Stroke Volume
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