The Effects of Calcium on ADH Action in Cortical Collecting Tubules Perfused InVitro

  • Stanley Goldfarb
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 151)


The effects of calcium on ADH action have been the object of intense study for 20 years (1). Extreme elevations in serosal calcium (Ca++) concentration (10 mM) have been shown to block ADH-induced water flow in the toad urinary bladder (1,2). To test the effects of smaller elevations of calcium level on ADH action in a mammalian system, studies were performed in the ADH responsive cortical collecting tubule, “light” segment (3).


Hydraulic Conductivity Calcium Level Mammalian System Intense Study Small Elevation 
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  1. 1.
    M.J. Peterson and I.S. Edelman, Calcium inhibition of the action of vasopressin on the urinary bladder of the toad. J. Clin. Invest. 43: 583 (1964).CrossRefGoogle Scholar
  2. 2.
    W.P. Argy Jr., J.S. Handler, and J. Orloff, Ca++ and Mg++ effects on toad bladder response to cyclic AMP, theophylline and ADH analogues. Am. J. Physiol. 213: 803 (1965).Google Scholar
  3. 3.
    M. Imbert, D. Chabardes, M. Montegut, A. Clique, and F. Morel, Vasopressin dependent adenylate cyclase in single segments of rabbit kidney tubule. Pflugers Arch. 357: 173 (1975).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Stanley Goldfarb
    • 1
  1. 1.Renal Electrolyte SectionHospital of the University of PennsylvaniaPhiladelphiaUSA

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