The Effects of Calcium on ADH Action in Cortical Collecting Tubules Perfused InVitro
The effects of calcium on ADH action have been the object of intense study for 20 years (1). Extreme elevations in serosal calcium (Ca++) concentration (10 mM) have been shown to block ADH-induced water flow in the toad urinary bladder (1,2). To test the effects of smaller elevations of calcium level on ADH action in a mammalian system, studies were performed in the ADH responsive cortical collecting tubule, “light” segment (3).
KeywordsHydraulic Conductivity Calcium Level Mammalian System Intense Study Small Elevation
- 2.W.P. Argy Jr., J.S. Handler, and J. Orloff, Ca++ and Mg++ effects on toad bladder response to cyclic AMP, theophylline and ADH analogues. Am. J. Physiol. 213: 803 (1965).Google Scholar