1,25-Dihydroxycholecalciferol (Calcitriol): Effect on Phosphate (PO4) Absorption by Isolated Pars Recta

  • Robert A. Peraino
  • Wadi N. Suki
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 151)


Phosphate handling by the kidney is influenced by a number of factors including extracellular fluid volume, plasma calcium concentration, bicarbonate administration, parathyroid hormone, and dietary phosphate balance. Vitamin D metabolites have also been demonstrated to augment renal phosphate absorption in the presence and absence of PTH (1–6). Bonjour, Preston and Fleisch have demonstrated that calcitriol increases phosphate excretion in the thyropara-thyroidectomized rat (7), and Gloor, Bonjour, Caverzasio and Fleisch demonstrated that calcitriol prevents the renal resistance to the Phosphaturic response to PTH during phosphate depletion (8). These investigators localized the site of action of calcitriol to the proximal convoluted tubule and beyond the point of micropuncture in the distal tubule in the rat (9).


Parathyroid Hormone Fluid Absorption Phosphate Transport Extracellular Fluid Volume Tubule Segment 
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  1. 1.
    Puschett, J.B., Morony, J., and Kurnick, W.S., 1972, Evidence for a direct action of cholecalciferol and 25-hydroxycholecalciferol on the renal transport of phosphate, sodium, and calcium, J. Clin. Invest., 51:373.PubMedCrossRefGoogle Scholar
  2. 2.
    Puschett, J.B., Beck, W.S., Jr., and Jelonek, A., 1975, Parathyroid hormone and 25-hydroxyvitamin D3: Synergistic and antagonistic effects on renal phosphate transport, Science, 190:473.PubMedCrossRefGoogle Scholar
  3. 3.
    Puschett, J.B., Beck, W.S., Jr., Jelonek, A., and Fernandez, P.C., 1974, Study of the renal tubular interactions of thyrocalcitonin, cyclic adenosine 3’,5’-monophosphate, 25-hydroxycholecalciferol, and calcium ion, J. Clin. Invest., 53:756.PubMedCrossRefGoogle Scholar
  4. 4.
    Costanzo, L.S., Sheehe, P.R., and Weiner, I.M., 1974, Renal actions of vitamin D in D-deficient rats, Amer. J. Physiol., 226:1490.PubMedGoogle Scholar
  5. 5.
    Popovtzer, M.M., Robinette, J.B., DeLuca, H.F., and Holick, M.D., 1974, The acute effect of 25-hydroxycholecalciferol on renal handling of phosphorus. Evidence for a parathyroid hormone-dependent mechanism, J. Clin. Invest., 53:913.PubMedCrossRefGoogle Scholar
  6. 6.
    Puschett, J.B., Fernandez, P.C., Bolye, LT., Gray, R.W., Omdahl, J.L., and DeLuca, H.F., 1972, The acute renal tubular effects of 1,25 dihydroxycholecalciferol, Proc. Soc. Exp. Biol. Med., 141:379.PubMedGoogle Scholar
  7. 7.
    Bonjour, J-P., Preston, C., and Fleisch, H., 1977, Effect of 1,25-dihydroxyvitamin D3 on the renal handling of Pi in thyropara-thyroidectomized rats, J. Clin. Invest., 60:1419.PubMedCrossRefGoogle Scholar
  8. 8.
    Gloor, H.J., Bonjour, J-P., Caverzasio, J., and Fleisch, H., 1979, Resistance to the Phosphaturic and calcemic actions of parathyroid hormone during phosphate depletion. Prevention by 1,25-dihydroxyvitamin D3, J. Clin. Invest., 63:371.PubMedCrossRefGoogle Scholar
  9. 9.
    Muhlbauer, R.C., Bonjour, J-P., and Fleisch, H., 1981, Tubular handling of Pi: localization of effects of 1,25(OH)2D3 and dietary Pi in TPTX rats, Amer. J. Physiol., 241:F123.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Robert A. Peraino
    • 1
  • Wadi N. Suki
    • 1
  1. 1.Baylor College of Medicine & The Methodist HospitalHoustonUSA

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