Renal Pi Transport in Young Growing and Adult Rats: Comparative Studies in Brush Border Membrane Vesicles (BBMV) and in Whole Kidney

  • J. Caverzasio
  • J.-P. Bonjour
  • H. Murer
  • H. Fleisch
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 151)


The question where and how the renal transport of inorganic phosphate (Pi) is regulated has been the subject of numerous investigations over the last few years. In this regard, the discovery of a sodium-dependent Pi transport system in the brush border membranes of the renal cortex (1) has been of particular interest. It gave rise to the question of whether the Pi transfer rate determined by this system across the luminal membrane of the proximal tubule would be the only limited and regulated step of the overall net tubular Pi reab-sorption. Therefore we have been particularly interested in studying the relationship between alterations in the overall tubular Pi reabsorptive capacity and changes in the Pi transport at the level of brush border membrane vesicles (BBMV) of the renal cortex of rats. In this investigation the alterations in the renal handling of Pi were provoked by variation in dietary Pi, removal of the parathyroid gland, chronic administration of either 1,25-dihydroxyvitamin D to thyroparathyroidectomized animals or the diphosphonate ethane-1-hydroxy-1,1-diphosphonate (2,3).


Proximal Tubule Renal Cortex Brush Border Membrane Vesicle Luminal Membrane Renal Handling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    N. Hoffmann, M. Thees, and R. Kinne, Phosphate transport by isolated renal brush border vesicles, Pflügers Arch. 362:147 (1976)PubMedCrossRefGoogle Scholar
  2. 2.
    R. Stoll, R. Kinne, H. Murer, H. Fleisch, and J.-P. Bonjour, Phosphate transport by rat renal brush border membrane vesicles: Influence of dietary phosphate, thyroparathyroidectomy, and 1,25-dihydroxyvitamin D3, Pflügers Arch. 380:47 (1979).PubMedCrossRefGoogle Scholar
  3. 3.
    R. Stoll, H. Murer, H. Fleisch, and J.-P. Bonjour, Effect of diphosphonate treatment on phosphate transport by renal brush border vesicles. Amer. J. Physiol. 239:F13 (1980).PubMedGoogle Scholar
  4. 4.
    J.-P. Bonjour, J. Caverzasio, H. Fleisch, R. Mühlbauer, and U. Tröhler, Renal handling of phosphate. Contr. Nephrol. 23:11 (1980).Google Scholar
  5. 5.
    R. C. Mühlbauer, J.-P. Bonjour, and H. Fleisch, Tubular localization of the adaptation to dietary phosphate in rats, Amer. J. Physiol. 233:F342 (1977).PubMedGoogle Scholar
  6. 6.
    R. C. Mühlbauer, J.-P. Bonjour, and H. Fleisch, Chronic thyroparathyroidectomy and tubular handling of phosphate: Increased reabsorption in late but not in early proximal tubule. Pflügers Arch. 388:185 (1980).PubMedCrossRefGoogle Scholar
  7. 7.
    R. C. Mühlbauer, J.-P. Bonjour, and H. Fleisch, Tubular handling of phosphate along the nephron of thyropara-thyroidectomized rats injected with ethane-1-hydroxy-1,1-diphosphonate, Clin. Sci. 60:171 (1981).PubMedGoogle Scholar
  8. 8.
    R. C. Mühlbauer, J.-P. Bonjour, and H. Fleisch, Tubular handling of Pi: localization of effects of 1,25(OH)2 D3 and dietary Pi in TPTX rats, Amer. J. Physiol. 241:F123 (1981).PubMedGoogle Scholar
  9. 9.
    J. Caverzasio, J.-P. Bonjour, H. Murer, and H. Fleisch, Adaptation of renal Pi transport in young growing and adult rats: Dissociation between changes in brush border membrane vesicles (BBMV) and in whole kidney, in: Abstracts 8th Internat. Congr. of Nephrology, Athens, CA-079 (1981).Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • J. Caverzasio
    • 1
  • J.-P. Bonjour
    • 1
  • H. Murer
    • 1
  • H. Fleisch
    • 1
  1. 1.Institute of PathophysiologyUniversity of BerneBerneSwitzerland

Personalised recommendations