The Adaptive System of the Tubular Transport of Phosphate

  • J.-P. Bonjour
  • J. Caverzasio
  • H. Fleisch
  • R. Mühlbauer
  • U. Troehler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 151)


The present report is an attempt to review the state of our knowledge concerning the adaptation of the tubular transport of Pi in relation with the homeostasis of Pi.


Adaptive System Brush Border Membrane Vesicle Renal Handling Dietary Phosphate Tubular Transport 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Webster’s New World Dictionary of the American Language. D. B. Guraluik, ed., The World Publishing Company, Celveland and New York (1966).Google Scholar
  2. 2.
    R. F. Pitts, “Physiology of the Kidney and Body Fluids”, Year Book Medical Publishers, Chicago (1968).Google Scholar
  3. 3.
    O. L. M. Bijvoet, D. B. Morgan, and P. Fourman, The assessment of phosphate reabsorption, Clin. Chim.Google Scholar
  4. 4.
    J. D. Crawford, M. M. Osborne jr., N. B. Talbot, L. M. Terry, and M. F. Morrill, The parathyroid glands and phosphorus homeostasis, J. Clin. Invest. 29:1448 (1950).PubMedCrossRefGoogle Scholar
  5. 5.
    E. L. Chambers jr., G. S. Gordan, L. Goldman, and E. C. Reifenstein jr., Tests for hyperparathyroidism: Tubular reabsorption of phosphate, phosphate deprivation and calcium infusion, J. Clin. Endocrinol. Metab. 16:1507 (1956).PubMedCrossRefGoogle Scholar
  6. 6.
    U. Troehler, J.-P. Bonjour, and H. Fleisch, Inorganic phosphate homeostasis. Renal adaptation to the dietary intake in intact and thyroparathyroidectomized rats. J. Clin. Invest. 57:264 (1976).CrossRefGoogle Scholar
  7. 7.
    T. H. Steele, and H. F. DeLuca, Influence of dietary phosphorus on renal phosphate reabsorption in the parathyyroid-ectomized rats, J. Clin. Invest. 57:867 (1976).PubMedCrossRefGoogle Scholar
  8. 8.
    J.-P. Bonjour, A. D. Care, and D. W. Pickard, Renal adaptation to changes in dietary phosphorus intake by thyroparathyroidectomized pigs, J. Physiol. 290:27 (1979).Google Scholar
  9. 9.
    R. C. Mühlbauer, J.-P. Bonjour, and H. Fleisch, Renal handling of phosphate (Pi) and calcium (Ca) in X-linked hypophosphatemic (HYP) mice, in: “Kidney and Body Fluids” (Vol. 11, in Advances in Physiological Sciences), Proc. 28th Int. Congress of Physiological Sciences, Budapest 1980, L. Takacs, ed., Pergamon Press, Budapest (1980).Google Scholar
  10. 10.
    J.-P. Bonjour, J. Caverzasio, H. Fleisch, R. Mühlbauer, and U. Tröhler, Renal handling of phosphate, Contr. Nephrol. 23:11 (1980).Google Scholar
  11. 11.
    U. Troehler, J.-P. Bonjour, and H. Fleisch, Plasma level and renal handling of Pi: Effect of overnight fasting with and without Pi supply, Amer. J. Physiol., in press.Google Scholar
  12. 12.
    T. H. Steele, J. L. Underwood, B. A. Stromberg, and C. A. Larmore, Renal resistance to parathyroid hormone during phosphorus deprivation, J. Clin. Invest. 58:1461 (1976).PubMedCrossRefGoogle Scholar
  13. 13.
    J.-P. Bonjour, U. Troehler, R. Mühlbauer, C. Preston, and H. Fleisch, Is there a bone-kidney link in the homeostasis of inorganic phosphate (Pi)? in: “Phosphate Metabolism” (Vol. 81 in Advances in Experimental Medicine and Biology), Proc. 2nd Int. Workshop on Phosphate, Heidelberg 1976, S. G. Massry and E. Ritz, eds., Plenum Press, New York London (1977).Google Scholar
  14. 14.
    H. J. Gloor, J.-P. Bonjour, J. Caverzasio, and H. Fleisch, Resistance to the Phosphaturie and calcemic actions of parathyroid hormone during phosphate depletion. Prevention by 1,25-dihydroxyvitamin D. J. Clin. Invest. 63:371 (1979).PubMedCrossRefGoogle Scholar
  15. 15.
    A. Frick, Reabsorption of inorganic phosphate in the rat kidney: I. Saturation of transport mechanism; II. suppression of fractional phosphate reabsorption due to expansion of extracellular fluid volume, Pflügers Arch. 304:351 (1968).PubMedCrossRefGoogle Scholar
  16. 16.
    J.-F. Boudry, ü. Troehler, M. Touabi, H. Fleisch, and J.-P. Bonjour, Secretion of inorganic phosphate in the rat nephron, Clin. Sci. Mol. Med. 48:475 (1975).Google Scholar
  17. 17.
    A. Frick, and I. Durasin, Maximal reabsorptive capacity for inorganic phosphate (TmPi) in the absence of parathyroid hormone in the rat: Decrease of the TmPi. during prolonged administration of phosphate and the role of calcium, Pflügers Arch. 377:9 (1978).PubMedCrossRefGoogle Scholar
  18. 18.
    H. Oberleitner, R. Greger, and F. Lang, Role of calcium in the decline of phosphate reabsorption during phosphate loading in acutely thyroparathyroidectomized rats, Pflügers Arch. 374::249 (1978).Google Scholar
  19. 19.
    R. Mühlbauer, J.-P. Bonjour, and H. Fleisch, Tubular localization of the adaptation to dietary phosphate in rats, Amer. J. Physiol. 233:F342 (1977).PubMedGoogle Scholar
  20. 20.
    R. Mühlbauer, J.-P. Bonjour, and H. Fleisch, Tubular handling of Pi: localization of effects of 1,25(OH)2 D3 and dietary Pi in TPTX rats, Amer. J. Physiol. 241:F123 (1981).PubMedGoogle Scholar
  21. 21.
    K. J. Ullrich, G. Rumrich, S. Klöss, Phosphate transport in the proximal convolution of the rat kidney. I. Tubular heterogeneity, effect of parathyroid hormone in acute and parathyroidectomized animals, and effect of phosphate diet. Pflügers Arch. 372:269 (1977).PubMedCrossRefGoogle Scholar
  22. 22.
    P. C. Brazy, J. W. McKeown, R. H. Harris, and V. W. Dennis, Comparative effects of dietary phosphate, unilateral nephrectomy, and parathyroid hormone on phosphate transport by the rabbit proximal tubule, Kidney Int. 17:788 (1980).PubMedCrossRefGoogle Scholar
  23. 23.
    R. Stoll, R. Kinne, H. Murer, H. Fleisch, and J.-P. Bonjour, Phosphate transport by rat renal brush border membrane vesicles: Influence of dietary phosphate, thyroparathyroidectomy, and 1,25-dihydroxyvitamin D3. Pflügers Arch. 380:47 (1979).PubMedCrossRefGoogle Scholar
  24. 24.
    S. A. Kempson, S. V. Shah, P. G. Werness, T. Berndt, P. H. Lee, L. H. Smith, F. G. Knox, and T. P. Dousa, Renal brush border membrane adaptation to phosphorus deprivation: Effects of fasting versus low-phosphorus diet. Kidney Int. 18:36 (1980).PubMedCrossRefGoogle Scholar
  25. 25.
    H. S. Tenenhouse, and C. R. Scriver, Renal adaptation to phosphate deprivation in the Hyp mouse with X-linked hypophosphatemia, Canad. J. Biochem. 57:938 (1979).CrossRefGoogle Scholar
  26. 26.
    P. Q. Barrett, J. M. Gertner, and H. Rasmussen, Effect of dietary phosphate on transport properties of pig renal microvillus vesicles, Amer. J. Physiol. 239:F352 (1980).PubMedGoogle Scholar
  27. 27.
    J. Caverzasio, J.-P. Bonjour, H. Murer, and H. Fleisch, Adaptation of renal Pi transport in young growing and adult rats: Dissociation between changes in brush border membrane vesicles (BBMV) and in whole kidney, abstract VIIIth Int. Congr. of Nephrology, Athens (1981).Google Scholar
  28. 28.
    J.-P. Bonjour, U. Troehler, C. Preston, and H. Fleisch, Parathyroid hormone and renal handling of Pi: effect of dietary Pi and diphosphonates, Amer. J. Physiol. 234:F497 (1978).PubMedGoogle Scholar
  29. 29.
    J. Caverzasio, J.-P. Bonjour, and H. Fleisch, Adaptation of tubular phosphate transport: Relation between phosphate requirement, as influenced by growth, and supply, in: “Phosphate and Minerals in Health and Disease” (Vol. 128, in Advances in Experimental Medicine and Biology), Proc. 4th Int. Workshop on Phosphate and Other Minerals, Strasbourg 1979, S. G. Massry, E. Ritz, and H. Jahn, eds., Plenum Press, New York and London (1980).Google Scholar
  30. 30.
    S. V. Shah, S. A. Kempson, T. E. Northrup, and T. P. Dousa, Renal adaptation to a low phosphate diet in rats, blockade by actinomycin D, J. Clin. Invest. 64:955 (1979).PubMedCrossRefGoogle Scholar
  31. 31.
    N. Beck, S. K. Webster, and H. J. Reineck, Effect of fasting on tubular phosphorus reabsorption, Amer. J. Physiol. 237:F241 (1979).PubMedGoogle Scholar
  32. 32.
    H. E. Ginn, and L. L. Shanbour, Phosphaturia in magnesiumdeficient rats, Amer. J. Physiol. 212:1347 (1967).PubMedGoogle Scholar
  33. 33.
    T. H. Steele, J. E. Engle, Y. Tanaka, R. S. Lorenc, K. L. Dudgeon, and H. F. DeLuca, Phosphatemic action of 1,25-dihydroxyvitamin D3, Amer. J. Physiol. 229:489 (1975).PubMedGoogle Scholar
  34. 34.
    J.-P. Bonjour, C. Preston, and H. Fleisch, Effect of 1,25-dihydroxyvitamin D3 on the renal handling of Pi in thyroparathyroidectomized rats, J. Clin. Invest. 60:1419 (1977).PubMedCrossRefGoogle Scholar
  35. 35.
    D. B. N. Lee, N. Braubar, M. W. Walling, V. Silis, H. E. Carlson, R. E. Grindeland, J. W. Coburn, and C. R. Kleeman, Role of growth hormone in experimental phosphorus deprivation in the rat, Calcif. Tissue Int. 32: 105 (1980).PubMedCrossRefGoogle Scholar
  36. 36.
    S. Moser, N. Brautbar, V. Gura, C. R. Kleeman, and S. G. Massry, On the mechanism of hypophosphaturia during acute and chronic dietary phosphate restriction, Min. Electr. Metab. 5:39 (1981).Google Scholar
  37. 37.
    N. Beck, Effects of dietary phosphorus (P) intake on renal actions of parathyroid hormone (PTH) and cyclic AMP (cAMP), Kidney Int. 10:487 (1976).CrossRefGoogle Scholar
  38. 38.
    K. Kurokawa, W. J. Kreusser, E. Aznar, E. Sachtjen, and S. G. Massry, Effects of parathyroid hormone and calcitonin on renal cyclic AMP and protein kinase activity during phosphate depletion. Min. Electr. Metab. 4:197 (1980).Google Scholar
  39. 39.
    W. J. Kreusser, K. Kurokawa, E. Aznar, and S. G. Massry, Phosphate depletion, Min. Electr. Metab. 5:30 (1978).Google Scholar
  40. 40.
    T. J. Berndt, F. G. Knox, and T. P. Dousa, Role of nicotine-adenine dinucleotide (NAD) in the Phosphaturic response to parathryoid hormone (PTH), Kidney Int. 19:108 (1981).Google Scholar
  41. 41.
    W. J. Kreusser, C. Descoeudres, Y. Oda, and S. G. Massry, Effect of phosphate depletion on renal gluconeogenesis, Min. Electr. Metab. 3:312 (1980).Google Scholar
  42. 42.
    G. E. Plante, C. Petitclerc, T. Nawar, and R. Erian, Increased phosphaturia during inhibition of renal alkaline phosphatase, Min. Electr. Metab. 2:258 (1979).Google Scholar
  43. 43.
    S. A. Kempson, J. K. Kim, T. E. Northrup, F. G. Knox, and T. P. Dousa, Alkaline phosphatase in adaptation to low dietary phosphate intake, Amer. J. Physiol. 237:E465 (1979).PubMedGoogle Scholar
  44. 44.
    H. S. Tenenhouse, C. R. Scriver, and E. J. Vizel, Alkaline phosphatase activity does not mediate phosphate transport in the renal-cortical brush-border membrane, Biochem. J. 190:473 (1980).PubMedGoogle Scholar
  45. 45.
    B. S. Levine, A. Hodsman, K. Ho, H. F. Shaw, B. Hirayama, I. Kippin, D. B. N. Lee, and J. W. Coburn, Early renal brush border adaptation to dietary phosphorus restriction, Kidney Int. 19:113 (1981).Google Scholar
  46. 46.
    J. Caverzasio, J.P. Bonjour, H. J. Gloor, and H. Fleisch, Parathyroid hormone (PTH) is not essential for adaptation of tubular phosphate (Pi) transport to chronic renal mass reduction, in: “Hormonal Control of Calcium Metabolism”, Proc. 7th Int. Conf. on Calcium Regulating Hormones, Estes Park USA, 1980, D. V. Cohn, R. V. Talmage, and J. L. Matthews, eds., Excerpta Medica, Amsterdam-Oxford-Princeton (1981).Google Scholar
  47. 47.
    R. Mühlbauer, J.-P. Bonjour, and H. Fleisch, Tubular handling of phosphate (Pi) and Ca in X-linked hypophosphatemic mice: Defective adaptation to Pi restriction associated with a renal Ca leak, in: “Hormonal Control of Calcium Metabolism”, Proc. 7th Int. Conf. on Calcium Regulating Hormones, Estes Park USA, 1980, D. V. Cohn, R. V. Talmage, and J. L. Matthews, eds., Excerpta Medica, Amsterdam-Oxford-Princeton (1981).Google Scholar
  48. 48.
    K. Insogna, A. Stewart, and J. Gertner, Impaired response to acute phosphorus (P) deprivation in sex-linked hypophosphatemia rickets (HR), in: program and abstracts of the 3rd Annual Scientific Meeting of the American Society for Bone and Mineral Research, Cincinnati, p 28A, (1981).Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • J.-P. Bonjour
    • 1
  • J. Caverzasio
    • 1
  • H. Fleisch
    • 1
  • R. Mühlbauer
    • 1
  • U. Troehler
    • 1
  1. 1.Department of PathophysiologyUniversity of BerneBerneSwitzerland

Personalised recommendations