Gene Mapping and Gene Transfer in Mammalian Cells

  • Frank H. Ruddle
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 50)


Somatic cell genetics provides a new approach to the genetic analysis of mammalian species* During the first decade of its use the rapid and simple methods of somatic cell genetics have been used to map over 200 genes in man (1,2). The total number now stands at more than 400. Somatic cell genetics depends on parasexual events detectable in somatic cells in vitro. These parasexual events result in the transfer of genetic information, and its fate in the recipient cell. Moreover, these methods, in combination with current recombinant DNA technology, provide different levels of genetic resolution, ranging from the chromosomal location of genes to the fine structural mapping of individual genes.


Human Chromosome Thymidine Kinase Recipient Cell Globin Gene Hybrid Cell Line 


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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Frank H. Ruddle
    • 1
  1. 1.Department of BiologyYale UniversityNew HavenUSA

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