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Somatic Cell Genetics pp 69–85Cite as

Expression of Liver Mono-Oxygenase Functions Induced by Xenobiotics

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Part of the book series: NATO Advanced Study Institutes Series ((NSSA,volume 50))

Abstract

Living cells possess accurately programed mechanisms for regulating the relative amounts of different proteins synthesized. Regulation of gene expression in somatic cells is complex, and is not yet completely understood, affording one of the most interesting and important challenges in contemporary biochemical research. In the highly differentiated eucaryotic cells of vertebrates, a large fraction of the genome is permanently repressed. Only a relatively small fraction of the total genome can be induced or depressed reversibly. These cells do in fact have the capacity for induction of some enzymes by their substrates, although their responses to inducing agents tend to be slow and less dramatic than in procaryotes.

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Authors and Affiliations

  1. Instituto Gulbenkian de Ciência, Ap. 14 - 2781, Oeiras, Codex - Portugal

    M. C. Lechner, C. M. Sinogas, M. T. Freire & J. Bràz

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  1. M. C. Lechner
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  1. Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, USA

    C. Thomas Caskey  & D. Christopher Robbins  & 

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© 1982 Plenum Press, New York

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Lechner, M.C., Sinogas, C.M., Freire, M.T., Bràz, J. (1982). Expression of Liver Mono-Oxygenase Functions Induced by Xenobiotics. In: Caskey, C.T., Robbins, D.C. (eds) Somatic Cell Genetics. NATO Advanced Study Institutes Series, vol 50. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4256-4_5

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