The Use of Mouse-Human and Human-Human Hybridomas in Human Genetics and Immunology

  • Carlo M. Croce
  • Alban Linnenbach
  • Thomas W. Dolby
  • Hilary Koprowski
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 50)


In order to investigate the molecular basis of human immunodeficiencies and to understand the immunological basis of human autoimmune diseases, it is important to be able to clone the genes for human immunoglobulin chains and the autoantibodies responsible for the pathogenesis of the autoimmune diseases respectively.


Measle Virus Human Immunoglobulin Hypoxanthine Phosphoribosyltransferase Subacute Sclerosing Panencephalitis Human Autoimmune Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Dolby, T.W., DeVuono J. and Croce, C.M. 1980. Proc. Natl. Acad. Sci. USA 77:6027–6031.PubMedCrossRefGoogle Scholar
  2. 2.
    Ricciardi, R.P., Miller, J.S. and Roberts, B.E. 1979. Proc. Natl. Acad. Sci. USA 76:4923–4931.CrossRefGoogle Scholar
  3. 3.
    Maxam, A. and Gilbert, W. 1980. Methods Enzymol. 65:499–560.PubMedCrossRefGoogle Scholar
  4. 4.
    Croce, C.M., Shander, M., Martinis, J., Cicurel, L., D’Ancona, G.G., Dolby, T.W. and Koprowski, H. 1979. Proc. Natl. Acad. Sci. USA 76:3416–3419.PubMedCrossRefGoogle Scholar
  5. 5.
    Kohler, C and Milstein, G. 1975. Nature (London) 256:495–497.CrossRefGoogle Scholar
  6. 6.
    Stephens, R.E., Pan, C, Ajiro, K., Dolby, T.W. and Borun, T.W. 1977. J. Biol. Chem. 252:166–172.PubMedGoogle Scholar
  7. 7.
    Marcu, K.B., Valbuena, O. and Perry, R.P. 1978. Biochemistry 17:1723–1733.PubMedCrossRefGoogle Scholar
  8. 8.
    Pelham, H. and Jackson, R.J. 1976. Eur. J. Biochem. 67:247–256.PubMedCrossRefGoogle Scholar
  9. 9.
    Wickens, M.P., Buell, G.N. and Schimke, R.T. 1978. J. Biol. Chem. 253:2483–2495.PubMedGoogle Scholar
  10. 10.
    Schenk, T.E., Rhodes, C, Rigby, P.W.J, and Berg, P. 1975. Proc. Natl. Acad. Sci. USA 72:984–993.CrossRefGoogle Scholar
  11. 11.
    Roychoudhury, R., Jay, E. and Wu, R. 1976. Nucleic Acids Res. 3:101–116.PubMedGoogle Scholar
  12. 12.
    Villa-Komaroff, L., Efstratiadis, A., Broome, S., Lomedico, P., Tizard, R., Naber, S.P., Chick, W.L. and Gilbert, W. 1978. Proc. Natl. Acad. Sci. USA 75:3727–3731.PubMedCrossRefGoogle Scholar
  13. 13.
    Enea, V., Vovis, G.F. and Zinder, N.D. 1975. J. Mol. Biol. 96:495–509.PubMedCrossRefGoogle Scholar
  14. 14.
    Sippel, A.Z., Land, H., Lindenmaier, W., Nguyon-Huu, M., Wurtz, J., Timmis, K.N., Giescoke, K. and Schultz, G. 1978. Nucleic Acids Res. 5:3275–3294.PubMedCrossRefGoogle Scholar
  15. 15.
    Denhardt, D. 1966. Biochem. Biophys. Res. Commun. 23:641–646.PubMedCrossRefGoogle Scholar
  16. 16.
    Humpheries, P., Old, R., Coggins, L.W., McShane, T., Watson, C. and Paul, J. 1978. Nucleic Acids Res. 5:905–924.CrossRefGoogle Scholar
  17. 17.
    Meyers, J.C., Spiegelman, S. and Kacian, D.L. 1977. Proc. Natl. Acad. Sci. USA 74:2840–2843.CrossRefGoogle Scholar
  18. 18.
    Rigby, P.W.J., Dieckmann, M., Rhodes, C. and Berg, P. 1977. J. Mol. Biol. 113:237–251.PubMedCrossRefGoogle Scholar
  19. 19.
    Maniatis, T., Jeffrey, A. and Van de Sande, A. 1975. Biol. Chemistry 14:3787–3794.Google Scholar
  20. 20.
    Kuperstock, Y.M. and Helsinki, D.R. 1973. Biochem. Biophys. Res. Commun. 54:1451–1459.CrossRefGoogle Scholar
  21. 21.
    Goldberg, M.L., Liftan, R.P., Stark, G.R. and Williams, J.G. 1979. Methods Enzymol. 68:206–220.PubMedCrossRefGoogle Scholar
  22. 22.
    Croce, CM., Linnenbach, A., Hall, W., Steplewski, Z. and Koprowski, H. 1980. Nature 288:488–489.PubMedCrossRefGoogle Scholar
  23. 23.
    Hall, W.W., Lamb, R.A. and Choppin, P.W. 1979. Proc. Natl. Acad. Sci. USA 76:2047–2051.PubMedCrossRefGoogle Scholar
  24. 24.
    Littlefield, J.W. 1964. Science 145:709–710.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Carlo M. Croce
    • 1
  • Alban Linnenbach
    • 1
  • Thomas W. Dolby
    • 1
  • Hilary Koprowski
    • 1
  1. 1.The Wistar Institute of Anatomy and BiologyPhiladelphiaUSA

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