Towards Mapping Genes to Chromosomes Using Two Dimensional Gel Electrophoresis of Proteins and Somatic Cell Hybridization. Preliminary Studies
Fusion of somatic cells followed by loss of chromosomes from one of the parents represents a unique tool to assign phenotypic traits to particular chromosomes or to regions of chromosomes(1–7). This approach, however, is limited by the small number of genetic markers available for the selection of hybrids(8) and more seriously by the lack of sensitive assays to determine how much information is coexpressed in the hybrids at the molecular level(6, 7, 9–13).
KeywordsCell Hybrid Mouse Chromosome Original Number Hypoxanthine Phosphoribosyltransferase Natural Science Research Council
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