Cell Hybridization: A Tool for the Study of Cell Differentiation
One of the many uses of somatic cell hybridization has been to explore the kinds of regulatory mechanisms responsible for the acquisition and the maintenance of the differentiated state. When this work was begun in the late sixties, it was believed that the genetic analysis of cell differentiation, achieved by analyzing the properties of hybrid cells resulting from the fusion of various kinds of differentiated cells, would make it possible to deduce the kinds of genetic mechanisms responsible for the expression of tissue-specific genes. Since that time, it has become clear that regulation in mammalian cells is far too complex to be dissected by this kind of genetic approach alone. Nevertheless, the results obtained do make it possible to eliminate some kinds of models of cell differentiation. In addition, these studies have revealed that fundamentally different mechanisms are involved in the heritable potential of cells to express tissue specific genes, and in the actual expression of these genes.
KeywordsSomatic Hybrid Hybrid Cell Somatic Cell Hybrid Parental Genome Gene Dosage Effect
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