Biological Effects of Low Energy Electromagnetic Fields on the Central Nervous System

  • W. Ross Adey
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 49)


There has been extensive speculation about the possibility of enhanced sensitivities of central nervous tissue to environmental electromagnetic fields. Brain tissue possesses its own well known intrinsic oscillating field, the electroencephalogram (EEG). The functional significance of this internal field has been a matter of conjecture. Based on classical membrane electrophysiology, the majority of opinion has most frequently dismissed it as merely “the noise of the brain’s motor.” Evidence that this may not be an accurate evaluation has come from a variety of studies of effects of imposed oscillating electromagnetic fields which induce weak extracellular electrochemical oscillations in the fluid surrounding brain cells, and which mimic in varying degrees components of the natural electrochemical oscillations of the EEG in the same domain of brain tissue.


Coherent State Microwave Field Dendritic Branch Cell Membrane Surface Calcium Efflux 
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  1. Adey, W.R., 1975, Evidence for cooperative mechanisms in the susceptibility of cerebral tissue to environmental and intrinsic electric fields, in: “Functional Linkage in Biomolecular Systems”, F.O. Schmitt, D.M. Schneider and D.M. Crothers, eds. Raven, New York. p. 325–342.Google Scholar
  2. Adey, W.R., 1979, Models of membranes of cerebral cells as substrates for information storage, BioSystems, 8: 163–178.CrossRefGoogle Scholar
  3. Adey, W.R., 1979, Experiment and theory in long-range interactions of electromagnetic fields at brain cell surfaces, in: “Magnetic Field Effects on Biological Systems”, T. Tenforde, ed. Plenum, New York. p. 57–78.CrossRefGoogle Scholar
  4. Adey, W.R., 1981a, Tissue interactions with nonionizing electromagnetic fields, Physiol. Rev. 61: 435–514.Google Scholar
  5. Adey, W.R. 1981b, Ionic nonequilibrium phenomena in tissue interactions with electromagnetic fields, in: “Biological Effects of Nonionizing Radiation”, K.H. Illinger, ed. American Chemical Society Symposium Series, No. 157. American Chemical Society, Washington, D.C. p. 271–297.CrossRefGoogle Scholar
  6. Adey, W.R., and Bawin, S.M., 1980, Nonequilibrium processes in binding and release of brain calcium by low-level electromagnetic fields, in: “Bioelectrochemistry: Ions, Surfaces, Membranes”, M. Blank, ed. American Chemical Society, Advances in Chemistry Series, No. 188. American Chemical Society, Washington, D.C. p. 361–378.CrossRefGoogle Scholar
  7. Adey, W.R., Bawin, S.M., and Lawrence, A.F., 1981, Nonlinear wave mechanismss in tissue-electromagnetic field interactions. Bioelectromagnetics Google Scholar
  8. Barnes, F.S., and Hu, C.L.J., 1977, Model for some nonthermal effects of radio and microwave fields on biological membranes, IEEE Trans. Microwave Theory Tech. 25: 742–746.MathSciNetADSCrossRefGoogle Scholar
  9. Bass, L., and Moore, W.J., 1968, A model of nervous excitation based on the Wien Dissociation effect, in: “Structural Chemistry and Molecular Biology,” A. Rich and C.M. Davidson, eds. Freeman, San Francisco. p. 356–368.Google Scholar
  10. Bawin, S.M., and Adey, W.R., 1976, Sensitivity of calcium binding in cerebral tissue to weak environmental electric fields oscillating at low frequency, Proc. Natl. Acad. Sci., USA, 73: 1999–2003.ADSCrossRefGoogle Scholar
  11. Bawin, S.M., Ade W, and Sabbot, I.M., 1978, Ionic factors in release of ~..Ca2 from chick cerebral tissue by electromagnetic fields, Proc. Natl. Acad. Sci., USA, 75: 6314–6318ADSCrossRefGoogle Scholar
  12. Bawin, S.M., Gavalas-Medici, R., and Adey, W.R., 1973, Effects of modulated very high frequency fields on specific brain rhythms in cats, Brain Res., 58: 365–384.CrossRefGoogle Scholar
  13. Bawin, S.M., Kaczmarek, L.K., and Adey, W.R., 1975, Effects of modulated VHF fields on the central nervous system, Ann. NY Acad. Sci., 247: 74–81.ADSCrossRefGoogle Scholar
  14. Bawin, S.M., Sheppard, A.R., and Adey, W.R., 1978, Possible mechanisms of weak electromagnetic field coupling in brain tissue, Bioelectrochem. Bioenergetics, 5: 67–76.CrossRefGoogle Scholar
  15. Benson, A.A., 1966, On the orientation of lipids in chloroplast and cell membranes, J. Amer. Oil Chem. Soc., 43: 265–270.MathSciNetCrossRefGoogle Scholar
  16. Bhaumik, D., Bhaumik, K., and Dutta-Roy, B., 1976, On the possibility of Bose condensation in the excitation of coherent modes in biological systems, Phys. Lett., 56A: 145–148.ADSGoogle Scholar
  17. Bullough, R.K., 1981, Bose-Fermi equivalence and soliton theory in solid-state physics, Nature, 292: 411–412.ADSCrossRefGoogle Scholar
  18. Davydov, A.S., 1977, Solitons as energy carriers in biological systems, Studia Biophysica, 62: 1–8.Google Scholar
  19. Davydov, A.S., 1979, Solitons in molecular systems, Physica Scripta, 20: 387–394.MathSciNetADSMATHCrossRefGoogle Scholar
  20. Edelman, G.M., 1976, Surface modulation in cell recognition and cell growth, Science, 192: 218–226.ADSCrossRefGoogle Scholar
  21. Einolf, C.W., and Carstensen, E.L., 1971, Low-frequency dielectric dispersion in suspensions of ion-exchange resins. J. Phys. Chem., 75: 1091–1099.CrossRefGoogle Scholar
  22. Fröhlich, H., 1968, Long-range coherence and energy storage in biological systems, Int. J. Quant. Chem., 2: 641–649.ADSCrossRefGoogle Scholar
  23. Fröhlich, H., 1975, The extraordinary dielectric properties of biological materials and the action of enzymes. Proc. Nat. Acad. Sci., USA, 72: 4211–4215.ADSCrossRefGoogle Scholar
  24. Kaczmarek, L.K, 1976, Frequency sensitive biochemical reactions, Biophys. Chem., 4: 249–252.CrossRefGoogle Scholar
  25. Kaczmarek, L.K., and Adey, W.R., 1974, Weak electric gradients change ionic and transmitter fluxes in cortex. Brain Res., 66: 537–540.CrossRefGoogle Scholar
  26. Kalmijn, A.J., 1980, Electromagnetic guidance systems in fishes, in: “Magnetic Field Effects on Biological Systems”, T. Tenforde, ed. Plenum, New York.Google Scholar
  27. Kretsinger, R., ed., 1981, Mechanisms of selective signaling by calcium, Neurosci. Res. Program Bull., 19: 213–332.Google Scholar
  28. Lawrence, A.F., and Adey, W.R., 1981, Nonlinear wave mechanisms in tissue-electromagnetic field interactions. Neurol. Res.Google Scholar
  29. Lin-Liu, S., and Adey, W.R., 1981, Low-frequency amplitude-modulated microwave fields change calcium efflux rates from synaptosomes. Bioelectromagnetics Google Scholar
  30. Matus, A., de Petris, S., and Raff, M.C., 1973, Mobility of concanavalin A receptors in myelin and synaptic membranes, Nature New Biology 244: 278–279.Google Scholar
  31. Neumann, E., and Katchalsky, A., 1972, Long-lived conformation changes induced by electric impulses in biopolymers, Proc. Natl. Acad. Sci., USA, 69: 993–997.ADSCrossRefGoogle Scholar
  32. Neumann, E., Nachmansohn, D., and Datchalsky, A., 1973, An attempt at an integral interpretation of nerve excitability, Proc. Natl. Acad. Sci.,USA, 70: 727–731.ADSCrossRefGoogle Scholar
  33. Pickard, W.F., and Rosenbaum, J.F., 1978, Biological effects of microwaves at the membrane level: two possible athermal electrophysiological mechanisms and a proposed experimental test, Math. Biosci., 39: 239–253.CrossRefGoogle Scholar
  34. Rabichev, L.Y., Ilynna, T.G., Ilynk, V.A., and Raku, P.V., 1976, Elektroson y ritmoteflperticheskii son, Korsakov J. Neuropath. Psychiat., 3: 443–446 (Russian).Google Scholar
  35. Redburn, D.A., Shelton, D., Cotman, C.W., 1976 Calcium-dependent release of exogenously loaded y-amino-[U-14C]butyrate from synaptosomes; time course of stimulation by potassium, veratridine, and the calcium ionophore, A23187, J. Neurochem., 26: 297–303.CrossRefGoogle Scholar
  36. Schwarz, G., 1967, A basic approach to a general theory for cooperative intramolecular conformation changes of linear biopolymers, Biopolymers, 5: 321–324.CrossRefGoogle Scholar
  37. Schwarz, G., 1975, Sharpness and kinetics of cooperative transitions, in: “Functional Linkage in Biomolecular Systems”, F.O. Schmitt, D.M. Schneider, and D.M. Crothers, eds. Raven Press, New York. p. 32–35.Google Scholar
  38. Schwarz, G., and Balthasar, W., 1970, Cooperative binding of linear biopolymers. 3. Thermodynamic and Kinetic analysis of the acridine orange-poly-L-glutamic acid system, Eur. J. Biochem., 12: 461–467.CrossRefGoogle Scholar
  39. Servantie, B., Servantie, A.M., and Etienne, J., 1975, Synchronization of cortical neurons by a pulsed microwave field as evidenced by spectral analysis of electrocorticograms from the white rat, Ann. NY Acad. Sci., 247: 82–86.ADSCrossRefGoogle Scholar
  40. Shepherd, G.M., 1979, “The Synaptic Organization of the Brain”, 2nd ed. Oxford University Press, New York, 436 pp.Google Scholar
  41. Sheppard, A.R., and Adey, W.R., 1979, The role of cell surface polarization in biological effects of extremely low frequency fields, U.S. Department of Energy Symposium Series, Nd. 50, “Biological Effects of Extremely Low Frequency Electromagnetic Fields”, Washington, D.C. pp. 147–158.Google Scholar
  42. Singer, S.J., and Nicolson, G.L., 1972, The fluid mosaic model of the sturcture of the cell membrane, Science, 175: 720–731.ADSCrossRefGoogle Scholar
  43. Takashima, S., Onoral, B., and Schwan, H.P., 1979, Effects of modulated RF energy on the EEG of mammalian brains, Radiat. Environ. Biophys., 16: 15–27.CrossRefGoogle Scholar
  44. Taylor, L.S., 1981, Athermal millimeter/microwave effects, Science Google Scholar
  45. Terenius, L., 1973, Stereospecific interaction between narcotic analgesics and a synaptic plasma membrane fraction of rat cerebral cortex, Acta Pharmacol. Toxicol., 32: 317–320.CrossRefGoogle Scholar
  46. Yahara, I., and Edelman, G.M., 1972, Restriction of the mobility of lymphocyte immunoglobulin receptors by concanavalin A, Proc. Natl. Acad. Sci., USA, 69: 608–612.ADSCrossRefGoogle Scholar
  47. Young, J.Z., 1951, “Doubt and Certainty in Science”, Oxford University Press, New York.Google Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • W. Ross Adey
    • 1
    • 2
  1. 1.Veterans Administration HospitalLoma LindaUSA
  2. 2.Departments of Physiology and SurgeryLoma Linda University, School of MedicineLoma LindaUSA

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