Selectivity in Cancer Chemotherapy
Over the past thirty years a large number of chemicals of different structures have been found to inhibit the growth of animal tumours. A small number of these have subsequently been used with usually limited success in the treatment of a few types of human cancer. Anticancer agents have been discovered by ‘screening’ usually against transplanted rodent tumours, by a study of analogues of known active compounds or by the rational design of chemicals based on a knowledge of the biochemistry of a particular cancer.
KeywordsMethotrexate Melphalan Alkaloid Porphyrin Propranolol
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