Selectivity in Cancer Chemotherapy

  • T. A. Connors
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 47)

Abstract

Over the past thirty years a large number of chemicals of different structures have been found to inhibit the growth of animal tumours. A small number of these have subsequently been used with usually limited success in the treatment of a few types of human cancer. Anticancer agents have been discovered by ‘screening’ usually against transplanted rodent tumours, by a study of analogues of known active compounds or by the rational design of chemicals based on a knowledge of the biochemistry of a particular cancer.

Keywords

Methotrexate Melphalan Alkaloid Porphyrin Propranolol 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    T.A. Connors, Drugs used in the treatment of cancer, Febs Lett. 57: 223 (1975).PubMedCrossRefGoogle Scholar
  2. 2.
    R.H. Blum and E. Frei, III. Comination chemotherapy, Methods in Cancer Research, XVII: 215 (1979).Google Scholar
  3. 3.
    H.E. Skipper, F.M. Schabel and W.S. Wilcox, Experimental evaluation of anticancer agents, Cancer Chemother. Rep. 51: 125 (1967).PubMedGoogle Scholar
  4. 4.
    T. Johima, M. Hashida, S. Muranishi and H. Sezaki, Mitomycin C-dextran conjugate: a novel high molecular weight prodrug of mitomycin C, J. Pharm. Pharmacol. 32: 30 (1980).Google Scholar
  5. 5.
    F.M. Sirotnak, P.L. Chellow and R.W. Brockman, Potential for exploitation of transport systems in anticancer drug design, Methods in Cancer Research, XVl: 381 (1979).Google Scholar
  6. 6.
    G. Abel, T.A. Connors, W.C.J. Ross, Nguyen-Hoang-Nam, H. Hoellinger and L. Pichat, The selective concentration of sulphadiazine and related compounds in malignant tissue, Europ. J. Cancer 9: 49 (1973).CrossRefGoogle Scholar
  7. 7.
    P.L. Carl, P.K. Chakravarty, J.A. Katzenellenbogen and M.J. Weber, Protease activated prodrugs for cancer chemotherapy, Proc. Nat. Acad. Sci. USA., 77: 2224 (1980).PubMedCrossRefGoogle Scholar
  8. 8.
    T.A. Connors, Alkylating agents, Topics in Current Chemistry 52: 141 (1974).PubMedGoogle Scholar
  9. 9.
    M.M. Manson, R.F. Legg, J.V. Watson, J.A. Green and G.E. Neal, An examination of the relative resistances to aflatoxin B and susceptibilities to y-glutamyl-p-phenylene diamine mustard of p-glutamyl transferase negative and positive cell lines, Carcinogenesis 2: 661 (1981).PubMedCrossRefGoogle Scholar
  10. 10.
    J.D. Chapman, A.J. Franko and J. Sharpun, A marker for hypoxic cells in tumours with potential clinical applicability, Br. J. Cancer 43: 546 (1981).PubMedCrossRefGoogle Scholar
  11. 11.
    M. Tsutsui, C. Carrano and E.A. Tsutsui, Tumor localizers, porphyrins and related compounds (unusual metalloporphyrins XXIII), Ann. N.Y. Acad. Sci. 244: 674 (1975).PubMedCrossRefGoogle Scholar
  12. 12.
    H.J.P. Ryser and W. Shen, 1975, Conjugation of methotrexate to poly (L-lysine) increases drug transport and overcomes drug resistance in cultured cells, Proc. Nat. Acad. Sci. USA., 75: 3867.CrossRefGoogle Scholar
  13. 13.
    M. Szekerke, R. Wade and M.E. Whisson, The use of macromolecules as carriers of cytotoxic groups (Part 1), Conjugates of nitrogen mustard with proteins, polypeptidyl proteins and polypeptides, Neoplasma 19: 199 (1972).PubMedGoogle Scholar
  14. 14.
    D.G. Gilliland, Z. Steplewski, R.J. Collier, K.F. Mitchell, T.H. Chang and H. Koprowski, Antibody directed cytotoxic agents. Use of monoclonal antibodies to direct the action of toxin A chains to colorectal carcinoma cells, Proc. Nat. Acad. Sci. USA., 77: 4539 (1980).PubMedCrossRefGoogle Scholar
  15. 15.
    M.R. Boyd, Evidence for the Clara cell as a site of cytochrome P450 dependent mixed function oxidase activity in lung, Nature (London) 269: 713 (1977).CrossRefGoogle Scholar
  16. 16.
    L.V. Feyns, J.A. Heisler, J.S. Driscoll and R.A. Adamson, Synthesis of propranolol mustard as a possible lung specific agent, J. Pharm. Sci. 69: 190 (1980).PubMedCrossRefGoogle Scholar
  17. 17.
    D.S. Zaharko, M. Przybylski and V.T. Oliverio, Binding of anticancer drugs to carrier molecules, Methods in Cancer Research XVI: 347 (1979).Google Scholar
  18. 18.
    N.B. Graham, Polymeric inserts and implants for the controlled release of drugs, British Polymer Journal, 10: 260 (1978).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • T. A. Connors
    • 1
  1. 1.Medical Research Council LaboratoriesMRC Toxicology UnitCarshaltonUK

Personalised recommendations