Targeting of Antitumour and Antiprotozoal Drugs by Covalent Linkage to Protein Carriers

  • André Trouet
  • Roger Baurain
  • Danièle Deprez-De Campeneere
  • Michèle Masquelier
  • Philippe Pirson
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 47)


The possibility of directing drugs selectively to their cellular targets was considered for the first time by Paul Ehrlich at the beginning of this century. It is, however, only since about twenty years that developments in biology and medicine have incited an increasing number of laboratories to try to translate this dream into reality. One of the most promising and most explored approaches is the linkage of very active but toxic pharmacological agents to carriers which will transport and target these selectively to sites of action.


Protein Carrier Lysosomal Enzyme Covalent Linkage Plasmodium Berghei Lysosomal Compartment 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • André Trouet
    • 1
  • Roger Baurain
    • 1
  • Danièle Deprez-De Campeneere
    • 1
  • Michèle Masquelier
    • 1
  • Philippe Pirson
    • 1
  1. 1.Laboratory of Physiological ChemistryUniversité Catholique de Louvain and International Institute of Cellular and Molecular PathologyBrusselsBelgium

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