Targeting of Antitumour and Antiprotozoal Drugs by Covalent Linkage to Protein Carriers
The possibility of directing drugs selectively to their cellular targets was considered for the first time by Paul Ehrlich at the beginning of this century. It is, however, only since about twenty years that developments in biology and medicine have incited an increasing number of laboratories to try to translate this dream into reality. One of the most promising and most explored approaches is the linkage of very active but toxic pharmacological agents to carriers which will transport and target these selectively to sites of action.
KeywordsProtein Carrier Lysosomal Enzyme Covalent Linkage Plasmodium Berghei Lysosomal Compartment
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