Liposomes and the Reticuloendothelial System: Interactions of Liposomes with Macrophages and Behavior of Liposomes In Vivo
Liposomes represent an attractive approach to the problem of controlled drug delivery. Liposomes composed of natural body constituents are biodegradable, very weakly immunogenic and possess limited intrinsic toxicity. A great number of drugs and macromolecules can be readily encapsulated within liposomes of various types using relatively simple and efficient procedures. Incorporation of a drug within liposomes produces drastic but predictable changes in the pharmacodynamic behaviour of the substance. Current approaches to the exploitation of liposomal delivery systems have been reviewed elsewhere (Juliano, 1981, 1980; Ryman this volume, Mayhew this volume).
KeywordsReticuloendothelial System Cytosine Arabinoside Latex Bead Mouse Peritoneal Macrophage Large Unilamellar Vesicle
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