Abstract
Liposomes, for many years a tool of the membranologists, have over the last 12 years been used in many other areas of research. Apart from their continuing use in membrane research, including immunological investigations, these phospholipid vesicles have found themselves the centre of attraction as possible carriers of materials of therapeutic interest.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Barratt, G.M., Ryman, B.E., Boden, J.A., Keep, P.A., Searle, F., Begent, R.H. and Bagshawe, K.D., 1981, Liposomal clearance of antibodies to tumour products: Possible improvement of tumour detection. Biochem. Soc. Trans. 9: in press.
Begent, R.H., Stanway, G., Jones, B.E., Bagshawe, K.D., Searle, F., Jewkes, R.F. and Vernon, P., 1980, Radioimmunolocalization of tumours by external scintigraphy after administration of 1311 antibody to human chorionic gonadotrophin: preliminary communication, J. R. Soc. Med 73: 624.
Campbell, P., Harding, N.G.L., Ryman, B.E. and Tyrrell, D.A., 1980, Redistribution and altered excretion of digoxin in rats receiving digoxin antibodies incorporated in liposomes, Eur. J. Biochem, 109: 87.
Goldenberg, D.M., Deland, F., Kim, E., Bennett, S., Primus, F.J., van Nagell, J.R., Estes, N., De Simone, P. and Rayburn, P., 1978, Use of radiolabelled antibodies to carcinoembryonic antigen for the detection and localization of diverse cancers by external photoscanning, New Engl. J. Med, 298: 1384.
Gregoriadis, G., 1979, in: “Drug Carriers in Biology and Medicine,” G. Gregoriadis, ed., Academic Press, London and New York.
Gregoriadis, G. and Ryman, B.E., 1972a, Fate of protein-containing liposomes injected into rats. An approach to the treatment of storage diseases, Eur. J. Biochem, 24: 485.
Gregoriadis, G. and Ryman, B.E., 1972b, Lysosomal localization of 8 fructofuranosidase-containing liposomes injected into rats: some implications in the treatment of genetic disorders. Biochem. J, 129: 123.
Hunter, W.M. and Greenwood, F.C., 1962, Preparation of iodine-131 labelled human growth hormone of high specific activity, Nature, 194: 495.
Kaye, S.B., Boden, J.A. and Ryman, B.E., 1981, The effect of liposome (phospholipid vesicle) entrapment of actinomycin D and methotrexate on the in vivo treatment of sensitive and resistant solid murine tumours, Eur. J. Cancer, 17: 279.
Kosloski, M.J., Rosen, F., Milholland, R.J. and Papahadjopoulos, D., 1978, Effect of lipid vesicle (liposome) encapsulation of methotrexate on its chemotherapeutic efficacy in solid rodent tumors, Cancer Res, 38: 28–48.
Osborne, M.P., RYtpan, B.E., Payne, J.H. and McCready, V.R., 1981a, The use of 9 mTc-labelled neutral liposomes in lymphoscintigraphy: A comparison of scintigram interpretations with node histology in a series of breast cancer patients, in “Progress in Radiopharmacology” vol. 2, P.H. Cox, ed., Elsevier/NorthHolland Biomedical Press, Amsterdam.
Osborne, M.P., Richardson, V.J., Jeyasingh, K. and Ryman, B.E., 1981b, Potential applications of radionuclide-labelled liposomes in the detection of the lymphatic spread of cancer, Int. J. Nucl. Med. Biol., submitted.
Papahadjopoulos, D., Poste, G., Vail, W.J. and Biedler, J.L., 1976, Use of lipid vesicles as carriers to introduce actinomycin D into resistant tumour cells, Cancer Res., 36: 2988.
Richardson, V.J., Jeyasingh, K., Jewkes, R.F., Ryman, B.E. and Tattersall, M.H.N., 1978a, Possible localization of 99mTclabelled liposomes: Effects of lipid composition, charge and liposome size, J. Nucl. Med, 19: 1049.
Richardson, V.J., Osborne, M.P., Jeyasingh, K., Ryman, B.E. and Burn, J.I., 1978b, Differential localization of (99mTc)technetium labelled liposomes in normal and tumour-bearing lymph nodes of the rat, Br. J. Cancer, 38: 177.
Richardson, V.J., Ryman, B.E., Jewkes, R.F., Jeyasingh, K., Tattersall, M.H.N., Newlands, E.S. and Kaye, S.B., 1979, Tissue distribution and tumour localization of 99m-technetium-labelled liposomes in cancer patients. Br. J. Cancer, 40: 35.
Rustum, Y.M., Dave, C., Mayhew, E. and Papahadjopoulos, D., 1979, Role of liposome type and route of adminsitration in the antitumor activity of liposome-entrapped 1 -D-arabinofuranosylcytosine against mouse L1210 leukaemia, Cancer Res, 39: 1390.
Ryman, B.E., Jewkes, R.F., Jeyasingh, K., Osborne, M.P., Patel, H.M., Richardson, V.J., Tattersall, M.H.N. and Tyrrell, D.A., 1978, Potential applications of liposomes to therapy, Ann. N.Y. Acad. Sci, 308: 281.
Ryman, B.E. and Tyrrell, D.A., 1979, Liposomes - Methodology and Applications, in “Lysosomes in Biology and Pathology”, vol. 6, J.T. Dingle, P.J. Jacques and I.H. Shaw, eds., Elsevier/NorthHolland Biomedical Press, Amsterdam.
Ryman, B.E. and Tyrrell, D.A., 1980, Liposomes - Bags of Potential, in: “Essays in Biochemistry” vol. 16, P.N. Campbell and R.D. Marshall, eds., Academic Press, London.
Schwartz, H.S., Sodergren, J.E., Sternberg, S.S. and Philips, P.S., 1966, Actinomycin D: Effects of Ridgway osteogenic sarcoma in mice, Cancer Res, 26: 1873.
Tyrrell, D.A., Campbell, P.I., Harding, N.G.L., Munroe, A. and Ryman, B.E., 1978, Antidigoxin antibody incorporation into liposomes - a potential therapy for digoxin toxicity, Biochem. Soc. Trans, 6: 1239.
Tyrrell, D.A., Heath, T.D., Colley, C.M. and Ryman, B.E., 1976, New aspects of liposomes, Biochem. Biophys. Acta, 457: 259.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Plenum Press, New York
About this chapter
Cite this chapter
Ryman, B.E., Barratt, G.M. (1982). Liposomes — Further Considerations of Their Possible Role as Carriers of Therapeutic Agents. In: Gregoriadis, G., Senior, J., Trouet, A. (eds) Targeting of Drugs. NATO Advanced Study Institutes Series, vol 47. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4241-0_14
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4241-0_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4243-4
Online ISBN: 978-1-4684-4241-0
eBook Packages: Springer Book Archive