Hyperthermia-Mediated Targeting of Liposome-Associated Anti-Neoplastic Drugs

  • Milton B. Yatvin
  • Theodore C. Cree
  • Jerry J. Gipp
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 47)


One of the major obstacles limiting the effectiveness of chemotherapeutic programmes is the inability of the present drug inventory to discriminate normal from malignant neoplastic tissue. As the search for selective anticancer drugs has been largely ineffective to date, considerable research effort has been directed toward the development of drug carrier systems1. One of the systems being investigated are closed vesicles composed primarily of phospholipids2,3. Liposomes have been extensively used as models3,4 for biological membrane research and have contributed to understanding the physico-chemical properties of biological membranes6,7. They have also advanced our understanding of cell-cell recognition8,9, fusion10,11 and protein-lipid interaction12,13. The self-assembly properties of phospholipid amphiphiles make possible the entrapment of water soluble compounds within the aqueous lumen of the liposome14. It became evident that entrapment of enzymes within liposomes might provide a therapeutic vehicle useful in treatment of diseases of enzyme deficiency15,16.


Water Soluble Compound Liposome Preparation Small Unilamellar Vesicle Local Hyperthermia Unilamellar Liposome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Milton B. Yatvin
    • 1
  • Theodore C. Cree
    • 1
  • Jerry J. Gipp
    • 1
  1. 1.Department of Human Oncology, WCCCUniversity of WisconsinMadisonUSA

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