Advertisement

Hyperthermia-Mediated Targeting of Liposome-Associated Anti-Neoplastic Drugs

  • Milton B. Yatvin
  • Theodore C. Cree
  • Jerry J. Gipp
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 47)

Abstract

One of the major obstacles limiting the effectiveness of chemotherapeutic programmes is the inability of the present drug inventory to discriminate normal from malignant neoplastic tissue. As the search for selective anticancer drugs has been largely ineffective to date, considerable research effort has been directed toward the development of drug carrier systems1. One of the systems being investigated are closed vesicles composed primarily of phospholipids2,3. Liposomes have been extensively used as models3,4 for biological membrane research and have contributed to understanding the physico-chemical properties of biological membranes6,7. They have also advanced our understanding of cell-cell recognition8,9, fusion10,11 and protein-lipid interaction12,13. The self-assembly properties of phospholipid amphiphiles make possible the entrapment of water soluble compounds within the aqueous lumen of the liposome14. It became evident that entrapment of enzymes within liposomes might provide a therapeutic vehicle useful in treatment of diseases of enzyme deficiency15,16.

Keywords

Water Soluble Compound Liposome Preparation Small Unilamellar Vesicle Local Hyperthermia Unilamellar Liposome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    G. Gregoriadis, ed., “Drug carriers in biology and medicine”, Academic Press, London, New York and San Francisco (1979).Google Scholar
  2. 2.
    D. Papahadjopoulos, ed., “Liposomes and their use in biology and medicine”, Ann. NY Acad. Sci. (1978).Google Scholar
  3. 3.
    A.C. Allison and G. Gregoriadis, eds., “Liposomes in biological systems”, John Wiley and Sons Ltd., New York (1980).Google Scholar
  4. 4.
    A.D. Bangham, H.W. Hill, and N.G.A. Miller in: “Methods in membrane biology” 1, E.D. Korn, ed., Plenum Press, New York (1974).Google Scholar
  5. 5.
    D. Papahadjopoulos and H.K. Kimelberg, in: “Progress in surface science”, S.G. Davison, ed., Pergamon Press, Oxford (1974).Google Scholar
  6. 6.
    A.D. Bangham, M.M. Standish, and J.C. Watkins, The action of steroids and streptolysin S on the permeability of phospholipid structures to cations, J. Mol. Biol., 13: 138 (1965).CrossRefGoogle Scholar
  7. 7.
    G. Gregoriadis, The carrier potential of liposomes in biology and medicine, (part I), New Engl. J. Med., 295: 704 (1976).PubMedCrossRefGoogle Scholar
  8. 8.
    H.K. Kimelberg and E.G. Mayhew, Properties and biological effects of liposomes and their uses in pharmacology and toxicology, CRC Crit. Rev. Toxicol., 6: 25 (1978).Google Scholar
  9. 9.
    M. Finkelstein and G. Weissmann, The introduction of enzymes into cells by means of liposomes, J. Lipid Res., 19: 289 (1978).PubMedGoogle Scholar
  10. 10.
    R.E. Pagano and J.N. Weinstein, Interactions of liposomes with mammalian cells, Ann. Rev. Biophys. Bioeng., 7: 435 (1978).CrossRefGoogle Scholar
  11. 11.
    F. Szoka, and D. Papahadjopoulos, Comparative properties and methods of preparation of lipid vesicles (Liposomes), Ann. Rev. Biophys. Bioeng., 9: 467 (1980).CrossRefGoogle Scholar
  12. 12.
    G. Gregoriadis, The carrier potential of liposomes in biology and medicine (part II), New Engl. J. Med., 295: 765 (1976).PubMedCrossRefGoogle Scholar
  13. 13.
    D.A. Tyrell, D. Heath, G.M. Colley and B.R. Ryman, New aspects of liposomes, Biochim. Biophys. Acta, 457: 259 (1976).Google Scholar
  14. 14.
    G. Tanford, “The hydrophobic effect: formation of micelles and biological membranes”, Wiley-Interscience, New York (1980).Google Scholar
  15. 15.
    J.N. Israelachvili, D.J. Mitchell and B.W. Ninham, Theory of self-assembly of hydrocarbon amphiphiles into micelles and bilayers, J. Chem. Soc. Faraday Trans., 72: 1525 (1976).CrossRefGoogle Scholar
  16. 16.
    A.D. Bangham, Lipid bilayers and biomembranes, Ann. Rev. Biochem., 41: 753 (1972).PubMedCrossRefGoogle Scholar
  17. 17.
    M.B. Yatvin, J.N. Weinstein, W.H. Dennis, and R. Blumenthal, Design of liposomes for enhanced local release of drugs by hyperthermia, Science, 202: 1290 (1978).PubMedCrossRefGoogle Scholar
  18. 18.
    J.N. Weinstein, R.L. Magin, M.B. Yatvin, and D.S. Zaharko, Liposomes and local hyperthermia: selective delivery of methotrexate to heated tumors, Science, 204: 188 (1979).PubMedCrossRefGoogle Scholar
  19. 19.
    J.N. Weinstein, R.L. Magin, R.L. Cysyk, and D.S. Zaharko, Treatment of solid L1210 murine tumors with local hyperthermia and temperature-sensitive liposomes containing methotrexate, Cancer Res., 40: 1388 (1980).PubMedGoogle Scholar
  20. 20.
    M.B. Yatvin, W. Kreutz, B.A. Horwitz and M. Shinitzky, pH-Sensitive liposomes: possible clinical implications, Science 210: 1253 (1980).Google Scholar
  21. 21.
    H.K. Kimelberg, Differential distribution of liposome-entrapped 3H-methotrexate and labelled lipids after intravenous injection in a primate, Biochim. Biophys. Acta, 448: 531 (1976).PubMedCrossRefGoogle Scholar
  22. 22.
    G. Scherphof, F. Roerdink, M. Waite, and J. Parks, Disintegration of phosphatidylcholine liposomes in plasma as a result of interaction with high-density lipoproteins, Biochim. Biophys. Acta, 542: 196 (1978).CrossRefGoogle Scholar
  23. 23.
    G. Scherphof, H. Morselt, J. Regts, and J.C. Wilschut, The involvement of the lipid phase transition in the plasma-induced dissolution of multilamellar phosphatidylcholine vesicles, Biochim. Biophys. Acta, 556: 196 (1979).CrossRefGoogle Scholar
  24. 24.
    G. Scherphof, The role of the liver in the clearance of liposomes from the blood, second WCCC international workshop on experimental oncology, Madison, Wisconsin (1981), Abs. 22.Google Scholar
  25. 25.
    M.B. Yatvin, H. Muhlensiepen, W. Porshcen, J.N. Weinstein, and L.E. Feinendegen, Selective delivery of liposome-associated cis-dichlorodiammineplatinum (II) by heat and its influence on tumor drug uptake and growth, Cancer Res., 41: 1602 (1981).PubMedGoogle Scholar
  26. 26.
    A. Watts, D. Marsh, and P.F. Knowles, Characterization of dimyristoyl phosphatidylcholine vesicles and their dimensional changes through the phase transition: molecular control of membrane morphology, Biochemistry, 17: 1792 (1978).PubMedCrossRefGoogle Scholar
  27. 27.
    P.M. Gullino, H. Grantham, S.H. Smith, and A.C. Haggerty, Modification of the acid-base status of the internal milieu of tumors, J. Natl. Cancer Inst., 34: 857 (1965).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Milton B. Yatvin
    • 1
  • Theodore C. Cree
    • 1
  • Jerry J. Gipp
    • 1
  1. 1.Department of Human Oncology, WCCCUniversity of WisconsinMadisonUSA

Personalised recommendations