The study of the interactions between proteins and DNA is one of the crucial problems in molecular biology given the central role they play in the biological activity of the genetic material. However the nature of the forces and mechanisms involved has remained elusive. Only very recently the first two structures of proteins which interact specifically with DNA has been reported1,2, but the nature of the complex they form with DNA is based only on speculation. We can hope that this situation will change in the near future, since there are now methods to obtain oligonucleotides suitable to form specific complexes with proteins.
KeywordsHigh Pass Filter Lithium Salt Major Groove Chromatin Fiber Helical Turn
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