The Structure and Dynamics of Water in Globular Proteins

  • J. L. Finney
  • J. M. Goodfellow
  • P. L. Poole
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 45)


Water plays more than a passive role in biomolecular processes that occur in aqueous media. Much of its involvement is often assigned to the so-called “hydrophobic interaction”, a process which, although well-characterised thermodynamically1, is poorly understood at the molecular level. In addition, there are other potentially large contributions to free energy changes accompanying such processes as protein-substrate binding or protein folding. These relate to hydrogen-bonding and entropic changes involving the solvent region2 and are similarly poorly understood.


Water Molecule Dipole Moment Protein Surface Dielectric Relaxation Bulk Water 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • J. L. Finney
    • 1
  • J. M. Goodfellow
    • 1
  • P. L. Poole
    • 1
  1. 1.Department of CrystallographyBirkbeck CollegeLondonEngland

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