Survey of Calcium Action in Stimulus-Secretion Coupling

  • Ronald P. Rubin


Before we survey the plethora of information concerning the regulatory role of calcium in the secretory process, it is necessary to review briefly the general features of this process in order to better appreciate how calcium acts in secretory systems. Under electron-microscopic analysis a typical feature of the secretory cell is the presence of numerous membrane-bound granules (100–400 nm in diameter) scattered throughout the cytoplasm that contain a variable quantity of electron-dense material. Small granular vesicles are also a uniform feature at chemical synapses, being situated close to the presynaptic nerve terminal.


Acinar Cell Adrenal Medulla Extracellular Calcium Secretory Response Enzyme Release 
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  1. *.
    8-(N,N-diethyIamino) octyl 3,4,5-trimethoxybenzoate)Google Scholar
  2. *.
    Paracrine secretion refers to diffusion of the chemical messenger from its cell of origin across intercellular spaces to its nearby target.Google Scholar
  3. *.
    Also designated LH-RH—luteinizing hormone-releasing hormone.Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Ronald P. Rubin
    • 1
  1. 1.Medical College of VirginiaVirginia Commonwealth UniversityRichmondUSA

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