Amphotericin B Toxicity for Epithelial Cells
One of the major goals of the studies of nephrotoxic agents is to determine where exactly a given drug acts. Does it act on the cell membrane and, if so, does it act on the lipid part of the membrane or on some specific transport site or receptor? It has been suggested (see Chapter 3, this volume) that the heavy metal uranyl nitrate may act on the sodium channels of the luminal membrane of the turtle bladder, and that the target structures for the aminoglycosides appear to be intracellular organelles, i.e., lysosomes, in the proximal tubular cells. In most instances, the precise sequence of events leading to injury and functional impairment remains unknown.
KeywordsLipid Bilayer Membrane Proximal Tubular Cell Renal Tubular Acidosis Luminal Membrane Permeability Defect
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