Heavy Metal Models of Experimental Acute Renal Failure
A large number of experimental models have been developed to evaluate the pathophysiology of acute renal failure (ARF). The diversity of these models of experimental ARF is a reflection both of the search for the “perfect” model as well as the heterogeneity of clinical ARF. In general, the experimental models of ARF may be subdivided into those induced with a nephrotoxin and those following a period of renal ischemia (Flamenbaum, 1973). A similar subdivision maybe made, when an etiologic event is known, for clinical instances of ARF. The lack of a single, universally accepted model used for the study of the pathophysiology of ARF thus reflects both the diversity of clinical ARF as well as a lack of uniform agreement concerning the pathophysiologic mechanism involved in the pathogenesis of ARF.
KeywordsGlomerular Filtration Rate Acute Renal Failure Renal Blood Flow Uranyl Nitrate Tubular Fluid
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