Mercuric Chloride-Induced Immunologically Mediated Diseases in Experimental Animals

  • B. Albini
  • I. Glurich
  • Giuseppe A. Andres


Large doses of cadmium, gold, or mercury salts produce acute toxic lesions, e.g., renal tubular necrosis (Gritzka and Trump, 1968). Administration of low doses of heavy metals may induce immunologically mediated diseases. Thus, membranous nephropathy has been described in humans in association with administration of mercury-containing compounds (Mendema et al., 1963). During the last decade, several animal models of chronic mercuric chloride-induced, immunologically mediated diseases have been established (Bariety et al., 1971; Roman-Franco et al., 1976, 1978; Sapin et al., 1977; Albini and Andres, 1982). In these models, pathogenesis involves autoimmunization to connective tissue components and development of immune complex-mediated pathology.


Glomerular Basement Membrane Mercuric Chloride Membranous Nephropathy Immune Deposit Tubular Basement Membrane 
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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • B. Albini
    • 1
  • I. Glurich
    • 1
  • Giuseppe A. Andres
    • 1
  1. 1.Departments of Microbiology, Pathology, and MedicineState University of New York at BuffaloBuffaloUSA

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