Mercuric Chloride-Induced Immunologically Mediated Diseases in Experimental Animals
Large doses of cadmium, gold, or mercury salts produce acute toxic lesions, e.g., renal tubular necrosis (Gritzka and Trump, 1968). Administration of low doses of heavy metals may induce immunologically mediated diseases. Thus, membranous nephropathy has been described in humans in association with administration of mercury-containing compounds (Mendema et al., 1963). During the last decade, several animal models of chronic mercuric chloride-induced, immunologically mediated diseases have been established (Bariety et al., 1971; Roman-Franco et al., 1976, 1978; Sapin et al., 1977; Albini and Andres, 1982). In these models, pathogenesis involves autoimmunization to connective tissue components and development of immune complex-mediated pathology.
KeywordsGlomerular Basement Membrane Mercuric Chloride Membranous Nephropathy Immune Deposit Tubular Basement Membrane
Unable to display preview. Download preview PDF.
- Albini, B., and Andres, G., 1982, Autoimmune disease induced in rabbits by administration of mercuric chloride. Evidence suggesting a role for antigens of the connective tissue matrix, in: Fogarty International Center Series, in press.Google Scholar
- Bariety, J., Druet, P., Laliberte, F., and Sapin, C., 1971, Glomerulonephritis with gamma and beta 1 C globulin deposits induced in rats by mercuric chloride, Am. J. Pathol. 65: 293.Google Scholar
- Bartolotti, S. R., 1977, Quantitative elution studies in experimental immune complex and nephrotoxic nephritis, Clin. Exp. Immunol. 29: 334.Google Scholar
- Bernaudin, J. F., Druet, E., Belair, M. F., Pinchon, M. C., Sapin, C., and Druet, P., 1979, Extrarenal immune complex type deposits induced by mercuric chloride in the Brown Norway rat, Clin. Exp.Immunol. 38: 265.Google Scholar
- Druet, P., Druet, E., Potdevin, F., and Sapin, C., 1978, Immune type glomerulonephritis induced by HgCl2 in the Brown-Norway rat, Ann. Immunol. (Inst. Pasteur) 129C: 777.Google Scholar
- Gritzka, T. L., and Trump, B. F., 1968, Renal tubular lesions caused by mercuric chloride, Am. J.Pathol. 52: 1225.Google Scholar
- Hinglais, N., Druet, P., Grossetete, J., Sapin, C., and Bariety, J., 1979, Ultrastructural study of nephritis induced in Brown-Norway rats by mercuric chloride, Lab. Invest. 41: 150.Google Scholar
- Roman-Franco, A. A., Turiello, M., Albini, B., Ossi, E., and Andres, G. A., 1976, Anti-basement membrane antibody (ABMAb) and immune complexes (IC) in rabbits injected with mercuric chloride, Kidney Int. 10: 549.Google Scholar
- Sapin, C., Druet, E., and Druet, P., 1977, Induction of anti-glomerular basement membrane antibodies in the Brown Norway rat by mercuric chloride, Clin. Exp. Immunol. 28: 173.Google Scholar
- Woodroffe, A. J., and Wilson, C. B., 1977, An evaluation of elution techniques in the study of immune complex glomerulonephritis, J. Immunol. 118: 1788.Google Scholar