Gold-Induced Autoimmune Reactions
Despite widespread clinical use of gold in the treatment of rheumatoid arthritis (RA) for over 50 years (Anon, 1979), little is known about the mechanism of the therapeutic action of gold and of its toxicity. The efficacy of gold in RA has been well documented, and despite its occasionally serious side effects, such as proteinuria, nephrotic syndrome, exfoliative dermatitis, aplastic anemia, agranulocytosis, and thrombocytopenic purpura, gold is today accepted in most countries as a first-line treatment for RA. In the 1970s gold salts were also introduced and successfully used in the treatment of pemphigus (Penneys et al., 1973).
KeywordsToxicity Polysaccharide Proteinuria Dextran Dermatitis
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