Drug-Induced Nephritides

Immediate Hypersensitivity Mechanism
  • Wayne A. Border


Tubular injury in the form of acute interstitial nephritis (AIN) or acute renal failure is a well-recognized complication of the administration of a variety of drugs or diagnostic agents, such as radiocontrast dye (Linton et al., 1980). The acute onset of AIN as well as the frequently associated findings of fever, rash, eosinophilia, and elevated IgE levels have strongly suggested an allergic or hypersensitivity reaction. The underlying immunologic mechanism(s) of these reactions has not been established and it will be the purpose of this chapter to examine the possible role of immediate hypersensitivity.


Interstitial Nephritis Acute Interstitial Nephritis Cromolyn Sodium Tubular Basement Membrane Reagenic Antibody 
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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Wayne A. Border
    • 1
  1. 1.Harbor-UCLA Medical CenterUniversity of California at Los Angeles School of MedicineTorranceUSA

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