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Drug-Induced Renal Lesions

Immunopathologic Mechanisms
  • Giuseppe A. Andres

Abstract

In the symposium on Drug Effects on the Kidney held in Sidney in 1979, practically all the papers delt with various aspects of nephrotoxicity. To my knowledge, there was not a session dedicated to renal injury related to drug-induced hypersensitivity reactions. The chapters in this section address this topic, a task made very difficult by the ignorance that still persists in this area of nephropathology. During the last decade, but especially during the last 3–4 years, drug-induced hypersensitivity has received increasing attention due to its importance in clinical medicine and the accelerated pace of progress in basic research. There is evidence, based on experimental models, human disease, or both, that the four main mechanisms of hypersensitivity, namely (1) antibody reacting with renal antigens, (2) immune complex formed in situ or in the circulation, (3) cell-mediated hypersensitivity, and (4) immediate IgE-type hypersensitivity, may by activated, independently or synergistically, by drugs and that the kidney may be a target organ.

Keywords

Immune Complex Mercuric Chloride Interstitial Nephritis Tubular Basement Membrane Accelerate Pace 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Giuseppe A. Andres
    • 1
  1. 1.Departments of Microbiology, Pathology and Medicine, School of MedicineState University of New York at BuffaloBuffaloUSA

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