Ultrastructural and Biochemical Localization of Organelle Damage from Nephrotoxic Agents

  • Bruce A. Fowler


The kidney is a frequent target organ for a variety of toxic agents due to its metabolic capacity for concentrating toxicants and/or metabolites during the excretory process and to the exquisite sensitivity of the numerous metabolic processes performed by this organ under normal circumstances and after injury. Toxic metals such as mercury, cadmium, chromium, and lead all show extensive kidney accumulation and toxicity to a host of renal metabolic processes. Other classes of toxicants, such as halogenated organics (carbon tetrachloride, cyclodiene pesticides, TCDD, and brominated alkyl compounds), are also capable of extreme toxicity following accumulation and interaction with renal microsomal enzyme systems.


Methyl Mercury Tubule Cell Mercuric Chloride Proximal Tubule Cell Environmental Toxicant 
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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Bruce A. Fowler
    • 1
  1. 1.Laboratory of PharmacologyNational Institute of Environmental Health SciencesUSA

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