During the last few years cadmium has been increasingly recognized as a dangerous environmental pollutant. Specifically, the subject of discussion has been the effect of cadmium on the kidney tubule, as it is the earliest health effect (“critical effect”) after long-term exposure (G. F. Nordberg, 1974; Friberg et al., 1974; Task Group on Metal Toxicity, 1976). Such renal effects occur with long-term accumulation of cadmium in the renal cortex when a certain tissue level (150–300 μg/g) is reached. An approximate estimation of the potential risk of renal effects can thus be made on the basis of calculations of the accumulation of cadmium in the kidney. In order to make adequate estimations of renal accumulation from data on intake, a detailed understanding is needed of the absorption, tissue distribution, retention, and excretion, i.e., the metabolism of cadmium.


Renal Cortex Body Burden Fecal Excretion Cadmium Chloride Kidney Cortex 
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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Gunnar F. Nordberg
    • 1
  1. 1.Department of Environmental HygieneUniversity of UmeaUmeaSweden

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