The Rat as an Animal Model of Lead Nephropathy

  • P. B. Hammond
  • C. D. Hong
  • E. J. O‘Flaherty
  • S. I. Lerner
  • I. B. Hanenson


Nephropathy is only one of a number of toxic effects of lead observed in humans. Others include anemia, peripheral neuropathy, and an array of signs and symptoms attributed to deranged function of the central nervous system. These effects have been reported principally in children of pre-school age and in adults occupationally exposed to lead. The frequency of occurrence and severity of adverse effects in these two populations has diminished over the years. There is still cause for concern, however, particularly in regard to occupational lead nephropathy. The death rate due to chronic nephritis among male lead workers in the first quarter of this century was twice as high as among non-lead-exposed males of the same social class (Lane, 1964). Even among men employed from 1947 to 1970 excess mortality due to nephritis appears to have occurred (Cooper and Gaffey, 1975). Recent studies of renal function in workers indicate that occupational lead nephropathy is still a major problem (Wedeen et al., 1979; Hong et al., 1980).


Glomerular Filtration Rate Serum Uric Acid Renal Blood Flow Lead Exposure Tubular Function 
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  1. Aperia, A., and Herin, P., 1975, Development of Glomerular perfusion rate and nephron filtration in rats 17–60 days old, Am. J. Physiol. 228:1319.Google Scholar
  2. Aviv, A., John, E., Bernstein, J., Goldsmith, D. I., and Spitzer, A., 1980, Lead intoxication during development: Its late effects on kidney function and blood pressure, Kidney Int. 17:430.CrossRefGoogle Scholar
  3. Chisolm, J. J., 1968, The use of chelating agents in the treatment of acute and chronic lead intoxication in childhood, J. Pediatr. 73:1.CrossRefGoogle Scholar
  4. Clarkson, T. W., and Kench, J. E., 1956, Urinary excretion of amino acids by men absorbing heavy metals, Biochem. J. 62:361.Google Scholar
  5. Cooper, W. C., and Gaffey, W. R., 1975, Mortality of lead workers, J. Occup. Med. 17:100.CrossRefGoogle Scholar
  6. Cramer, K., Goyer, R. A., Jagenburg, R., and Wilson, M. H., 1974, Renal ultrastructure, renal function, and parameters of lead toxicity in workers with different periods of lead exposure Br. J. Ind. Med. 31:113.Google Scholar
  7. Falk, G., 1955, Maturation of renal function in infant rats, Am. J. Physiol. 181:157.Google Scholar
  8. Galle, P., and Morel-Maroger, L., 1965, Les lesions renales du saturnisme humain et experimental, Nephron 2:213.CrossRefGoogle Scholar
  9. Gerhardt, R. E., Crecelius, E. A., and Hudson, J. B., 1980, Trace element content of moonshine, Arch Environ. Health 35:332.CrossRefGoogle Scholar
  10. Goyer, R. A., 1971, Lead and the kidney, Curr. Top. Pathol. 55:147.Google Scholar
  11. Goyer, R. A., Tsuchiya, K., Leonard, D. L., and Kahyo, H., 1972. Aminoaciduria in Japanese workers in the lead and cadmium industries, Am. J. Clin. Pathol. 57:635.Google Scholar
  12. Hammond, P. B., Lerner, S. I., Gartside, P. S., Hanenson, J. B., Roda, S. B., Foulkes, E. C., Johnson, D. R., and Pesce, A. J., 1980, The relationship of biological indices of lead exposure to the health status of workers on a secondary lead smelter, J. Occup. Med. 22:475.Google Scholar
  13. Henderson, D. A., 1958, The aetiology of chronic nephritis in Queensland, Med. J. Aust. 1:371.Google Scholar
  14. Hong, C. D., Hanenson, I. B., Lerner, S., Hammond, P. B., Pesce, A. J., and Pollak, V. E., 1980, Occupational exposure to lead: Effects on renal function, Kidney Int. 18:489.CrossRefGoogle Scholar
  15. Horster, M., and Lewy, J. E., 1970, Filtration fraction and extraction of PAH during neonatal period in the rat, Am. J. Physiol. 219:1061.Google Scholar
  16. Johnson, D. R., and Kleinman, L. I., 1979, Effects of lead exposure on renal function in young rats, Toxicol. Appl. Pharmacol. 48:361.CrossRefGoogle Scholar
  17. Lane, R. E., 1964, Health control in inorganic lead industries, Arch. Environ. Health 8:243.Google Scholar
  18. Lilis, R., Gavrilescu, N., Nestorescu, B., Dumitriu, C., and Roventa, A., 1968, Nephropathy in chronic lead poisoning, Br. J. Ind. Med. 25:196.Google Scholar
  19. Morgan, J. M., Hartley, M. W., and Miller, R. E., 1966, Nephropathy in chronic lead poisoning, Arch. Intern. Med. 118:17.CrossRefGoogle Scholar
  20. Radocevic, Z., Saric, M., Beritic, T., and Knezevic, J., 1961, The kidney in lead poisoning, Br. J. Ind. Med. 18:222.Google Scholar
  21. Richet, G., Albahary, C., Morel-Maroger, L., Guillaume, P., and Galle, P., 1966, Les alterations renales dans 23 cas de saturnisme professionnel, Bull. Soc. Med. Hop. Paris 117:441.Google Scholar
  22. Sandstead, H. H., Michelakis, A. M., and Temple, T. E., 1970, Lead intoxication. Its effect on the renin-adlosterone response to sodium deprivation, Arch. Environ. Health 20:356.Google Scholar
  23. Smith, H. W., Goldring, W., Chasis, H., Ranges, H. A., and Bradley, S. E., 1943, Application of saturation methods to the study of glomerular and tubular function in the human kidney, J. Mt. Sinai Hosp. (NY) 10:59.Google Scholar
  24. Tepper, L. B., 1963, Renal function subsequent to childhood plumbism, Arch. Environ. Health 7:82.Google Scholar
  25. Wedeen, R. P., Maesaka, J. K., Weiner, B., Lipat, G. A., Lyons, M. M., Vitale, L. F., and Joselow, M. M., 1975, Occupational lead nephropathy, Am. J. Med. 59:630.CrossRefGoogle Scholar
  26. Wedeen, R. P., Mallik, D. K., and Batuman, V., 1979. Detection and treatment of occupational lead nephropathy, Arch. Intern. Med. 139:53.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • P. B. Hammond
    • 1
  • C. D. Hong
    • 2
  • E. J. O‘Flaherty
    • 1
  • S. I. Lerner
    • 1
  • I. B. Hanenson
    • 2
  1. 1.Department of Environmental HealthUniversity of Cincinnati Medical CenterCincinnatiUSA
  2. 2.Department of MedicineUniversity of Cincinnati Medical CenterCincinnatiUSA

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