Abstract
Nephropathy is only one of a number of toxic effects of lead observed in humans. Others include anemia, peripheral neuropathy, and an array of signs and symptoms attributed to deranged function of the central nervous system. These effects have been reported principally in children of pre-school age and in adults occupationally exposed to lead. The frequency of occurrence and severity of adverse effects in these two populations has diminished over the years. There is still cause for concern, however, particularly in regard to occupational lead nephropathy. The death rate due to chronic nephritis among male lead workers in the first quarter of this century was twice as high as among non-lead-exposed males of the same social class (Lane, 1964). Even among men employed from 1947 to 1970 excess mortality due to nephritis appears to have occurred (Cooper and Gaffey, 1975). Recent studies of renal function in workers indicate that occupational lead nephropathy is still a major problem (Wedeen et al., 1979; Hong et al., 1980).
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© 1982 Springer Science+Business Media New York
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Hammond, P.B., Hong, C.D., O‘Flaherty, E.J., Lerner, S.I., Hanenson, I.B. (1982). The Rat as an Animal Model of Lead Nephropathy. In: Porter, G.A. (eds) Nephrotoxic Mechanisms of Drugs and Environmental Toxins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4214-4_23
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DOI: https://doi.org/10.1007/978-1-4684-4214-4_23
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