Pathology of Acute Renal Failure

  • Jeffrey I. Kreisberg
  • Erve G. J. Matthys
  • Manjeri A. Venkatachalam


Acute renal failure (ARF) can be defined as an abrupt decline in renal function sufficient to result in retention of nitrogenous waste. In this chapter we will describe and discuss, with an emphasis on structure-function correlations, a major subset of the clinical syndrome of ARF, that is, acute tubular necrosis (ATN). By definition, the term ATN includes all forms of acute urinary suppression in which tubular injury of acute onset is the primary basis for renal failure, and excludes all other causes of ARF, such as pre-renal azotemia, interstitial nephritis, glomerulonephritis, disseminated intravascular coagulation with renal cortical necrosis, organic vascular disease, and obstruction of the lower urinary tract (Robbins and Cotran, 1979).


Acute Renal Failure Proximal Tubule Mercuric Chloride Acute Tubular Necrosis Proximal Tubule Cell 
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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Jeffrey I. Kreisberg
    • 1
  • Erve G. J. Matthys
    • 1
  • Manjeri A. Venkatachalam
    • 1
  1. 1.Departments of Pathology and MedicineUniversity of Texas Health Science Center at San AntonioSan AntonioUSA

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