Current Concepts of Tubulointerstitial Nephritis

  • Ramzi S. Cotran


The purpose of this chapter is to summarize current views on the morphologic and clinical definition of interstitial nephritis, since many of the environmental agents, toxins, and drugs discussed in this book cause renal injury which affects primarily renal tubules and interstitium. It is generally agreed that a purely morphologic definition or classification of interstitial nephritis is of little value, since the histologic alterations are relatively nonspecific, and give little indication of etiology and pathogenesis. Rather, the terms interstitial nephritis or tubulointerstitial nephritis (or nephropathy) are used to describe a diverse group of renal disorders, caused by a variety of etiologic agents, in which the predominant morphologic involvement is in the tubules and the interstitium.


Vesicoureteral Reflux Interstitial Nephritis Acute Interstitial Nephritis Tubulointerstitial Nephritis Reflux Nephropathy 
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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Ramzi S. Cotran
    • 1
  1. 1.Department of PathologyBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA

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