Over three decades have elapsed since the identification of Chlortetracycline, the first tetracycline antibiotic. Since that time a large number of other tetracycline congeners have been isolated (from the products of fungal fermentation) and synthesized (by chemical alterations of the basic molecule). Seven congeners are currently available as broad-spectrum antibiotics in the United States: Chlortetracycline (CTC), Oxytetracycline (OTC), tetracycline (TC), demeclocycline (DMCTC), methacycline (MOTC), doxycycline (DOOTC), and minocycline (DDDTC)


Adenylate Cyclase Nephrogenic Diabetes Insipidus Fanconi Syndrome Renal Epithelium Toad Urinary Bladder 
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  1. Albert, A., and Rees, C. W., 1956, Avidity of the tetracyclines for the cations of metals, Nature 177:433.CrossRefGoogle Scholar
  2. Anderson, R. J., Gambertoglio, J. G., and Schrier, R. W., 1976, Clinical Use of Drugs in Renal Failure, Charles C. Thomas, Springfield, Illinois, p. 53.Google Scholar
  3. Benitz, K.-F., and Diermeier, H. F., 1964, Renal toxicity of tetracycline degradation products, Proc. Soc. Exp. Biol. Med. 115:930.Google Scholar
  4. Blackwood, R. K., and English, A. R., 1970, Structure-activity relationships in the tetracycline series, in: Advances in Applied Microbiology, (D. Perlman and W. Umbreit, eds.), Volume 13, Academic Press, New York, p. 237.Google Scholar
  5. Braden, G., Geheb, M., and Cox, M., 1980a, Renal toxicity of demeclocycline in patients with edematous disorders, Clin. Res. 28:655.Google Scholar
  6. Braden, G., Geheb, M., Singer, I., and Cox, M., 1980b, Lithium- and demeclocycline-induced natriuresis: Studies in toad urinary bladders, Clin. Res. 28:439.Google Scholar
  7. Carrilho, F., Bosch, J., Arroyo, V., Antoni, M., Viver, J., and Rodes, J., 1977, Renal failure associated with demeclocycline in cirrhosis, Ann. Intern. Med. 87:195.Google Scholar
  8. Castell, D. O., and Sparks, H.A., 1965, Nephrogenic diabetes insipidus due to demethylchlortetracycline hydrochloride, J. Am. Med. Assoc. 193:237.CrossRefGoogle Scholar
  9. Chan, S., 1979, Water diuretic activity of demeclocycline in rats, Fed. proc. 38:749.Google Scholar
  10. Cleveland, W. W., Adams, W. C., Mann, J. B., and Nyhan, W. L., 1965, Acquired Fanconi syndrome following degraded tetracycline, J. Pediatr. 66:333.CrossRefGoogle Scholar
  11. Cox, M., and Singer, I., 1976a, Inhibition of ADH-induced water flow by tetracyclines in toad urinary bladder: Fluorescence studies of drug-protein binding, Fed. Proc. 35:915.Google Scholar
  12. Cox, M., and Singer, I., 1976b, Inhibition of ADH-induced water flow in the toad urinary bladder by tetracyclines: Correlation of physiological effect with epithelial cell protein binding, Clin. Res. 24:397.Google Scholar
  13. Cox, M., Guzzo, J., Huber, G., and Singer, I., 1977a, Inhibition of ADH-stimulated water flow in toad urinary bladders by tetracyclines: pH-dependence and lack of correlation with antibacterial activity, Kidney Int. 12:554.Google Scholar
  14. Cox, M., Guzzo, J., Morrison, G., and Singer, I., 1977b, Demeclocycline and therapy of hyponatremia, Ann. Intern. Med. 86:113.Google Scholar
  15. Cox, M., Guzzo, J., Shook, A., Huber, G., and Singer, I., 1979, Effects of tetracyclines on aldosterone-and insulin-mediated Na+ transport in the toad urinary bladder, Biochim. Biophys. Acta 552:162.CrossRefGoogle Scholar
  16. DeTroyer, A., 1977, Demeclocycline treatment for syndrome of inappropriate antidiuretic hormone secretion, J. Am. Med. Assoc. 237:2723.CrossRefGoogle Scholar
  17. DeTroyer, A., Pilloy, W., Broeckaert, I., and Demanet, J.-C., 1976, Demeclocycline treatment of water retention in cirrhosis, Ann. Intern. Med. 85:336.Google Scholar
  18. Doluisio, J. T., and Martin, A. N., 1963a, Metal complexation of the tetracycline hydrochlorides, J. Med. Chem. 6:16.CrossRefGoogle Scholar
  19. Doluisio, J. T., and Martin, A. N., 1963b, The binding of tetracycline analogs to conalbumin in the absence and presence of cupric ions, J. Med. Chem. 6:20.CrossRefGoogle Scholar
  20. Dousa, T. P., and Wilson, D. M., 1974, Effects of demethylchlortetracycline on cellular action of antidiuretic hormone in vitro, Kidney Int. 5:279.CrossRefGoogle Scholar
  21. Feldman, H., and Singer, I., 1974, Comparative effects of tetracyclines on water flow across toad urinary bladders, J. Pharmacol. Exp. Ther. 190:358.Google Scholar
  22. Forrest, J. N., Jr., Cox, M., Hong, C., Morrison, G., Bia, M., and Singer, I., 1978, Superiority of demeclocycline over lithium in the treatment of chronic syndrome of inappropriate secretion of antidiuretic hormone, N. Engl. J. Med. 298:173.CrossRefGoogle Scholar
  23. Franklin, T. J., 1963, The inhibition of incorporation of leucine into protein of cell-free systems from rat liver and Escherichia coli by Chlortetracycline, Biochem. J. 87:449.Google Scholar
  24. Frimpter, G. W., Timpanelli, A. E., Eisenmenger, W. J., Stein, H. S., and Ehrlich, L. I., 1963, Reversible “Fanconi syndrome” caused by degraded tetracycline, J. Am. Med. Assoc. 184:111.CrossRefGoogle Scholar
  25. Fulop, M., and Drapkin, A., 1965, Potassium-depletion syndrome secondary to nephropathy apparently caused by “outdated tetracycline,” N. Engl. J. Med. 272:986.CrossRefGoogle Scholar
  26. Geheb, M., and Cox, M., 1980, Renal effects of demeclocycline, J. Am. Med. Assoc. 243:2519.CrossRefGoogle Scholar
  27. Goldman, R., and Hall, L. M., 1960, Studies on renal toxicity of demethylchlortetracycline, Science Information Exchange (final report of research project Z0–10444-C2, May 29, 1961) (listed in Med. Res. Vet. Adm. 1960, p. 130).Google Scholar
  28. Gross, J. M., 1963, Fanconi syndrome (adult type) developing secondary to the ingestion of outdated tetracycline, Ann. Intern. Med. 68:523.Google Scholar
  29. Guzzo, J., Cox, M., Kelly, A. B., and Singer, I., 1978, Tetracycline-induced inhibition of Na+ transport in the toad urinary bladder, Am. J. Physiol. 235:F359.Google Scholar
  30. Kelly, R. G., Peets, L. M., and Hoyt, K. D., 1969, A fluorometric method of analysis for tetracycline, Analytical Biochem. 28:222.CrossRefGoogle Scholar
  31. Kohn, K. W., 1961a, Determination of tetracyclines by extraction of fluorescent complexes. Application to biological materials, Analytical Chem. 33:862.CrossRefGoogle Scholar
  32. Kohn, K. W., 1961b, Mediation of divalent metal ions in the binding of tetracycline to macromolecules, Nature 191:1156.CrossRefGoogle Scholar
  33. Lowe, M. B., and Tapp, E., 1966, Renal damage caused by anhydro-4-epi-tetracycline, Arch. Pathol. 81:362.Google Scholar
  34. Martin, S. R., 1979, Equilibrium and kinetic studies on the interactions of tetracyclines with calcium and magnesium, Biophys. Chem. 10:319.CrossRefGoogle Scholar
  35. Miller, P. D., Linas, S. L., and Schrier, R. W., 1980, Plasma demeclocycline levels and nephrotoxicity—correlation in hyponatremic cirrhotic patients, J. Am. Med. Assoc. 243:2513.CrossRefGoogle Scholar
  36. Mitscher, L. A., 1978, The Chemistry of the Tetracycline Antibiotics. Medicinal Research Series, Volume 9 (G. L. Grunewald, ed.), Dekker, New York.Google Scholar
  37. Obek, A., Petorak, I., Eroglu, L., and Gurkan, A., 1974, Effects of tetracycline on the dog kidney—a functional and ultrastructural study, Israel J. Med. Sci. 10:765.Google Scholar
  38. Oster, J. R., Epstein, M., and Ulano, H. B., 1976, Deterioration of renal function with demeclocycline administration, Curr. Ther. Res. 20:794.Google Scholar
  39. Pestka, S., 1971, Inhibitors of ribosome functions, Annu. Rev. Microbiol. 25:487.CrossRefGoogle Scholar
  40. Roth, H., Becker, K. L., Shalhoub, R. J., and Katz, S., 1967, Nephrotoxicity of demethylchlortetracycline hydrochloride, Arch. Intern. Med. 120:433.CrossRefGoogle Scholar
  41. Shils, M. E., 1962, Some metabolic aspects of tetracyclines, Clin. Pharmacol. Ther. 3:321.Google Scholar
  42. Shils, M. E., 1963, Renal disease and the metabolic effects of tetracycline, Ann. Intern. Med. 58:389.Google Scholar
  43. Singer, I., and Rotenberg, D., 1973, Demeclocycline-induced nephrogenic diabetes insipidus: in-vivo and in-vitro studies, Ann. Intern. Med. 79:679.Google Scholar
  44. Wilson, D. M., Perry, H. O., Sams, W. M., Jr., and Dousa, T. P., 1973, Selective inhibition of human distal tubular function by demeclocycline, Curr. Ther. Res. 15:734.Google Scholar
  45. Zegers de Beyl, D., Naeije, R., and DeTroyer, A., 1978, Demeclocycline treatment of water retention in congestive heart failure, Br. Med. J. 1:760.CrossRefGoogle Scholar
  46. Zusman, R. M., Keiser, H. R., and Handler, J. S., 1978, Effect of adrenal steroids on vasopressin-stimulated PGE synthesis and water flow, Am. J. Physiol. 234:F532.Google Scholar

Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Malcolm Cox
    • 1
  1. 1.Renal-Electrolyte Section, Department of MedicinePhiladelphia Veterans Administration Medical Center and University of Pennsylvania School of MedicinePhiladelphiaUSA

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