Aminoglycoside Interactions with Other Drugs

Clinical and Toxicologic Implications
  • Friedrich C. Luft


Aminoglycoside antibiotics account for a large percentage of nephrotoxin-induced acute renal failure in humans. Clinically, other drugs are also frequently implicated. Such drugs include chemotherapeutic agents, anesthetics, and several antimicrobial agents. Not infrequently, patients who are critically ill receive one or more potentially nephrotoxic drugs during the course of aminoglycoside therapy. Thus attention has been directed to the possibility that interactions exist between the aminoglycosides and other pharmacologic agents which may modulate aminoglycoside nephrotoxicity. In addition, aminoglycoside nephrotoxicity is influenced by several nonpharmacologic factors. These include the presence of acidemia, chronic osmotic diuresis, and the state of sodium and potassium balance. When considering the risks of aminoglycoside therapy, these features must all be taken into account (Bennett et al., 1980).


Acute Renal Failure Mercuric Chloride Nephrotoxic Effect Newborn Rabbit Plasma Creatinine Concentration 
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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Friedrich C. Luft
    • 1
  1. 1.Department of Medicine, Nephrology SectionIndiana University School of MedicineIndianapolisUSA

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