Aminoglycoside Nephrotoxicity

Lysosomal and Mitochondrial Alterations in Rat Kidneys after Aminoglycoside Treatment
  • J. P. Morin
  • G. Viotte
  • J. P. Bendirdjian
  • B. Olier
  • J. P. Fillastre
  • M. Godin


Aminoglycosides are basic organic compounds with pKa varying between 7.5 and 8.0. These molecules have low molecular weights, are highly water-soluble, are lightly bound to plasma proteins, and are not metabolized in the body. In view of their very wide antibacterial spectrum, aminoglycosides are an important class of antimicrobial agents. Although they are oto- and nephrotoxic, these agents are commonly used in clinical treatment.


Brush Border Fabry Disease Proximal Tubule Cell Proximal Tubular Cell Kidney Cortex 
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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • J. P. Morin
    • 1
  • G. Viotte
    • 1
  • J. P. Bendirdjian
    • 1
  • B. Olier
    • 1
  • J. P. Fillastre
    • 1
  • M. Godin
    • 1
  1. 1.Tissue Physiology GroupUniversity of RouenRouenFrance

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