Antibiotic Nephrotoxicity

An Overview
  • George A. Porter


The percent distribution among recognized causes of acute renal failure has undergone a change during the last decade. Prior to 1970 the frequency of nephrotoxin-induced acute renal failure was 9% (Levinsky and Alexander, 1976), which in the last decade has risen to over 15% in series reporting consecutively occurring cases (McMurray et al., 1978; Anderson et al., 1977; Galpin et al., 1978). Antibiotics continue as the most frequently cited etiology of nephrotoxin-induced acute renal failure, with contrast agents a distant second (Porter and Bennett, 1980). Within the antibiotic category, aminoglycosides are the leader in causing renal injury.


Glomerular Filtration Rate Acute Renal Failure Proximal Tubular Cell Renal Tubular Acidosis Renal Plasma Flow 
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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • George A. Porter
    • 1
  1. 1.Department of MedicineOregon Health Sciences UniversityPortlandUSA

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