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Antibiotic Nephrotoxicity

An Overview
  • George A. Porter

Abstract

The percent distribution among recognized causes of acute renal failure has undergone a change during the last decade. Prior to 1970 the frequency of nephrotoxin-induced acute renal failure was 9% (Levinsky and Alexander, 1976), which in the last decade has risen to over 15% in series reporting consecutively occurring cases (McMurray et al., 1978; Anderson et al., 1977; Galpin et al., 1978). Antibiotics continue as the most frequently cited etiology of nephrotoxin-induced acute renal failure, with contrast agents a distant second (Porter and Bennett, 1980). Within the antibiotic category, aminoglycosides are the leader in causing renal injury.

Keywords

Glomerular Filtration Rate Acute Renal Failure Proximal Tubular Cell Renal Tubular Acidosis Renal Plasma Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Anderson, R. J., Linas, S. L., Berns, A. S., Henrich, W. L., Miller, T. R., Gabow, P. A., and Schrier, R. W., 1977, Non-oliquric acute renal failure, N. Engl. J. Med. 296:1134.CrossRefGoogle Scholar
  2. Andreoli, T., 1973, On the anatomy of amphotericin B-cholesterol pores in lipid bilayer membranes, Kidney Int. 4:337.CrossRefGoogle Scholar
  3. Butler, W. T., Bennett, J. E., and Aling, D. W., 1964, Nephrotoxicity of amphotericin B, early and late effect in 81 patients, Ann. Intern. Med. 61:175.Google Scholar
  4. Fanestil, D. D., 1968, Amphotericin B inhibition of active PAH transport, J. Lab. Clin. Med. 71:548.Google Scholar
  5. Galpin, J. E., Shinaberger, J. H., Stanley, T. M., Blumenkrantz, M. J., Bayer, A. S., Friedman, G. S., Montgomerie, J. Z., Guze, L. B., Coburn, J. W., and Glassock, R. J., 1978, Acute interstitial nephritis due to methicillin, Am. J. Med. 65:756.CrossRefGoogle Scholar
  6. Gerkens, J. F., and Branch, R. A., 1980, The influence of sodium status and furosemide on canine acute amphotericin B nephrotoxicity, J. Pharmacol. Exp. Ther. 214:306.Google Scholar
  7. Gouge, T. H., and Andriole, V. T., 1971, An experimental model of amphotericin B nephrotoxicity with renal tubular acidosis, J. Lab. Clin. Med. 78:713.Google Scholar
  8. Jose, P. A., Eisner, G. M., Hollerman, C. E., and Calcagno, P. L., 1971, Acute renal effects of amphotericin B, Proc. Soc. Exp. Biol. Med. 137:224.Google Scholar
  9. Levinsky, N. G., and Alexander, E. A., 1976, Acute renal failure, in: The Kidney (B. M. Brenner and F. C. Rector, Jr., eds.), Saunders, Philadelphia, Pennsylvania, p. 807.Google Scholar
  10. McMurray, S. D., Luft, F. C., Maxwell, D. R., Hamburger, R. J., Futty, D., Szwed, J. J., Lavelle, K. I., and Kleit, S. A., 1978, Prevailing patterns and predictor variables in patients with acute tubular necrosis, Arch. Intern. Med. 138:950.CrossRefGoogle Scholar
  11. McMurtry, R. J., and Mitchell, J. R., 1977, Renal and hepatic necrosis after metabolic activation of 2 substituted furans and thiophenes, including furosemide and cephaloridine, Toxicol. Appl. Pharmacol. 42:285.CrossRefGoogle Scholar
  12. Parker, R. A., Bennett, W. M., and Porter, G. A., 1982, Animal models in the study of aminoglycoside nephrotoxicity, in: The Aminoglycosides: Microbiology, Clinical Use and Toxicity (A. Whelton and H. Neu, eds.), Dekker, New York, p. 235.Google Scholar
  13. Pastoriza-Munoz, E., Bowman, R. L., and Kaloyanides, G. J., 1979, Renal tubular transport of genta-micin in the rat, Kidney Int. 16:440.CrossRefGoogle Scholar
  14. Porter, G. A., and Bennett, W. M., 1980, Nephrotoxin-induced acute renal failure, in: Contemporary Issues in Nephrology, Volume 6, Acute Renal Failure (B. M. Brenner and J. H. Stein, eds.), Churchill Livingstone, New York, p. 123.Google Scholar
  15. Schor, N., Ichikawa, I., Rennke, H. G., Troy, J. Z., and Brenner, B. M., 1981, Pathophysiology of altered glomerular function in aminoglycoside-treated rats, Kidney Int. 19:288.CrossRefGoogle Scholar
  16. Senekjian, H. O., Knight, T. F., and Weinman, E. J., 1981, Micropuncture study of the handling of gentamicin in the rat kidney, Kidney Int. 19:416.CrossRefGoogle Scholar
  17. Thurau, K., and Boylan, J. W., 1976, Acute renal success, Am. J. Med. 61:308.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • George A. Porter
    • 1
  1. 1.Department of MedicineOregon Health Sciences UniversityPortlandUSA

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