Principles and Application of Positron Emission Tomography in Neuroscience

  • Jonathan D. Brodie
  • Nora Volkow
  • John Rotrosen


Positron Emission Tomography (PET) is a new nuclear medicine technique which evolved from the need to establish the relationship among the functional activity of the brain, its metabolic rate, and its anatomic structure. This technique allows the detection of the three-dimensional distribution within the brain of a previously administered positron-emitting radionuclide. Although similar in principle to quantitative autoradiography, it has the advantage of providing functional information of a structure in a living organism. Positron emission tomography incorporates principles from both transmission computed tomography and the uptake and flow techniques initially developed by Kety and Schmidt1 but has the advantage of being able to give information for localized regions of the brain. This information is based on the detection of the annihilation energy produced when a positron emitted from a radionuclide-labeled compound interacts with an electron in the tissue.


Positron Emission Tomography Cerebral Blood Flow Glucose Metabolism Visual Cortex Primary Visual Cortex 


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  1. 1.
    Kety, S. S., and Schmidt, C. F., 1948, J. Clin. Invest. 27:476–483.PubMedCrossRefGoogle Scholar
  2. 2.
    Wolf, A. P., 1981, Semin. Nucl. Med. 11:2–12.PubMedCrossRefGoogle Scholar
  3. 3.
    Brownell, G. L., Correia, J. A., and Zamenhay, R. G., 1978, Recent Advances in Nuclear Medicine, Volume 5 (J. N. Lawrence and T. F. Budinger, eds.), Grune & Stratton, New York, pp. 1–47.Google Scholar
  4. 4.
    Derenzo, S. E., Banchero, P. G., and Cahoon, J. L., 1978, IEEE Trans. Nucl. Sci. 25:341–349.Google Scholar
  5. 5.
    Ter-Pogossian, M. M., Mullani, N. A., Ficke, D. C, Markham, J., and Snyder, D. L., 1981, J. Comput. Assist. Tomogr. 5:227–239.PubMedCrossRefGoogle Scholar
  6. 6.
    Raichle, M. E., 1979, Brain Res. Rev. 1:47–68.CrossRefGoogle Scholar
  7. 7.
    Mazziota, J. C., Phelps, M. E., Plummer, D., and Kuhl, D. E., 1981, J. Comput. Assist. Tomogr. 5(5):734–743.CrossRefGoogle Scholar
  8. 8.
    Ter-Pogossian, M. M., 1981, Semin. Nucl. Med. 11:13–23.PubMedCrossRefGoogle Scholar
  9. 9.
    Mullani, N. A., Ficke, C, and Ter-Pogossian, M. M., 1980, IEEE Trans. Nucl. Sci. 27:572–575.CrossRefGoogle Scholar
  10. 10.
    Budinger, T. F., 1978, A Primer on Reconstruction Algorithms, World Federation of Nuclear Medicine and Biology, pp. 1–38.Google Scholar
  11. 11.
    Ter-Pogossian, M. M., Raichle, M. E., and Sobel, B. E., 1980, Sci. Am. 243:170–181.PubMedCrossRefGoogle Scholar
  12. 12.
    Lenzi, G. L., Jones, T. M., McKenzie, C. G., Buckingham, P. D., Clark, J. C, and Moss, S., 1978, J. Neurol. Neurosurg. Psychiatry 41:1–10.PubMedCrossRefGoogle Scholar
  13. 13.
    Comar, D., Maziere, M., Godot, J. M., Berger, G., and Soussaline, F., 1979, Nature 280:329–331.PubMedCrossRefGoogle Scholar
  14. 14.
    Tewson, T. J., Raichle, M. E., and Welch, M. J., 1980, Brain Res. Rev. 193:291–295.Google Scholar
  15. 15.
    Gelbard, A., 1981, J. Label. Compd. Ratiopharm, 18:933–945.CrossRefGoogle Scholar
  16. 16.
    Shive, C. Y., Fowler, J. S., and Mac Gregor, R. R., 1979, Radiopharmaceuticals 11:259–264.Google Scholar
  17. 17.
    Knust, E. J., Kupfernagel, C, and Stocklin, G., 1979, J. Nucl. Med. 20:1170–1175.PubMedGoogle Scholar
  18. 18.
    Sokoloff, L., Reivich, M., Kennedy, C, Des Rosiers, M. H., Patlak, C. S., Pettigrew, K. D., Sakurada, O., and Shinohara, N., 1977, J. Neurochem. 28:897–916.PubMedCrossRefGoogle Scholar
  19. 19.
    Huang, S. C., Phelps, M. E., Hoffman, J. E., Sideris, K., Selin, C. J., and Kuhl, D. E., 1980, Am. J. Physiol. 238:69–82.Google Scholar
  20. 20.
    Phelps, M. E., Huang, S. C., Hoffman, E. J., Selin, C, Sokoloff, L., and Kuhl, D. E., 1979, Ann. Neurol. 6:371–388.PubMedCrossRefGoogle Scholar
  21. 21.
    Phelps, M. E., 1981, Semin. Nucl. Med. 11:32–49.PubMedCrossRefGoogle Scholar
  22. 22.
    Raichle, M. E., Welch, M. J., Grubb, R. L., Higgins, C. S., Ter-Pogossian, M. M., and Larson, K. B., 1978, Science 199:986–987.PubMedCrossRefGoogle Scholar
  23. 23.
    Reivich, M., Kuhl, D., Wolf, A., Greenberg, J., Phelps, M., Ido, T., Casella, V., Fowler, J., Hoffman, E., Alavi, A., Som, P., and Sokoloff, L., 1979, Circ. Res. 44:127–137.PubMedCrossRefGoogle Scholar
  24. 24.
    Scheinberg, P., and Stead, E. A., 1949, J. Clin. Invest. 28:1163–1171.PubMedCrossRefGoogle Scholar
  25. 25.
    Jones, T., Chesler, D. A., and Ter-Pogossian, M. M., 1976, Br. J. Radiol. 49:339–343.PubMedCrossRefGoogle Scholar
  26. 26.
    Subramanyam, R., Alpert, N. M., Hoop, B., Brownell, G. L., and Taveras, J. M., 1978, J.Nucl. Med. 19:48–53.PubMedGoogle Scholar
  27. 27.
    Raichle, M. E., 1981, Fed. Proc. 40:2331–2334.PubMedGoogle Scholar
  28. 28.
    Raichle, M. E., Grubb, R. L., Gado, M. H., Eichung, J. O., and Ter-Pogossian, M. M., 1976, Arch. Neurol. 33:523–526.PubMedCrossRefGoogle Scholar
  29. 29.
    Raichle, M. E., Grubb, R. L., and Higgins, C. S., 1979, Brain Res. 166:413–417.PubMedCrossRefGoogle Scholar
  30. 30.
    Yamamoto, Y. L., Thompson, C. J., Meyer, E., Robertson, J. S., and Feidel, W., 1977, J. Comput. Assist. Tomogr. 1:43–56.PubMedCrossRefGoogle Scholar
  31. 31.
    Ericson, K., Bergstrom, M., and Erikson, L., 1980, J. Comput. Assist. Tomogr. 4:737–745.PubMedCrossRefGoogle Scholar
  32. 32.
    Frackowiak, R. S., Lenzi, G. L., Jones, T., and Heather, J., 1980, J. Comput. Assist. Tomogr. 4:727–736.PubMedCrossRefGoogle Scholar
  33. 33.
    Ter-Pogossian, M. M., Klein, M. S., and Markham, J., 1980, Circulation 61:242–255.PubMedCrossRefGoogle Scholar
  34. 34.
    Phelps, M. E., Hoffman, E. J., and Raybaud, C., 1977, Stroke 8:694–702.PubMedCrossRefGoogle Scholar
  35. 35.
    Alavi, A., Reivich, M., Greenberg, J., Hand, P., Rosenquist, A., Rintelmann, W., Christman, D., Fowler, J., Goldman, A., Mac Gregor, R., and Wolf, A., 1981, Semin. Nucl. Med. 11:24–31.PubMedCrossRefGoogle Scholar
  36. 36.
    Sokoloff, L., 1981, Fed. Proc. 40:2311–2316.PubMedGoogle Scholar
  37. 37.
    Greenberg, J. H., Reivich, M., Alavi, A., Hand, P., Rosenquist, A., Rintelmann, W., Stein, A., Tusa, R., Dann, R., Christman, D., Fowler, J., MacGregor, B., and Wolf, A., 1981, Science 212:678–680.PubMedCrossRefGoogle Scholar
  38. 38.
    Phelps, M. E., and Kuhl, D. E., 1981, Science 211:1445–1448.PubMedCrossRefGoogle Scholar
  39. 39.
    Phelps, M. E., Mazziotta, J. C., Kuhl, D. E., Nuwer, M., Packwood, J., and Metter, J., 1981, Neurology (Minneap.) 31:517–529.CrossRefGoogle Scholar
  40. 40.
    Miller, J. A., 1981, Sci. News, 119:76–78.CrossRefGoogle Scholar
  41. 41.
    Kuhl, D. F., Engel, J., Phelps, M. E., and Selin, C., 1980, Ann. Neurol. 8:348–360.PubMedCrossRefGoogle Scholar
  42. 42.
    Kuhl, D. E., Phelps, M. E., Kowell, A. P., Metter, J. E., Selin, C., and Winter, J., 1980, Ann.Neurol. 8:47–60.PubMedCrossRefGoogle Scholar
  43. 43.
    Ferris, S. H., De Leon, M. J., Wolf, A., Farkas, T., Christman, D. R., Reisberg, B., Fowler,Google Scholar
  44. J. S., MacGregor, R., Goldman, A., George, A. E., and Rampai, S., 1980, Neurobiol. Aging 1:127–131.CrossRefGoogle Scholar
  45. 44.
    Frackowiack, R. S., Pozzilli, C, Legg, N. J., Du Boulay, G. H., Marshall, J., Lenzi, G. L., and Jones, T., 1981, J. Cerebral Blood Flow Metab. [Suppl.] 1:5453–5454.Google Scholar
  46. 45.
    Farkas, T., Reivich, M., Alavi, A., Greenberg, J. H., Fowler, J. S., MacGregor, R. R., Christman, D. R., and Wolf, A., 1980, Cerebral Metabolism and Neural Function (J. V. Passonneau, R. A. Hawkins, W. D. Lust, and F. A. Welsh, eds.), Williams & Wilkins, Baltimore, pp. 403–408.Google Scholar
  47. 46.
    Buchsbaum, M. S., Kessler, R., Bunney, W. E., Cappelletti, J., Coppola, R., van Kammen, D. P., Nigal, F., Waters, R., Sokoloff, L., and Ingvar, D., 1981, J. Cerebral Blood Flow Metab. [Suppl.] 1:5457–5458.Google Scholar
  48. 47.
    Kuhl, D., Phelps, M., Markham, C, Winter, J., Metter, J., and Rieoe, W., 1981, J. Cerebral Blood Flow Metab. [Suppl.] 1:5459–5460.Google Scholar
  49. 48.
    Metter, J. E., Wasterlain, C. G., Kuhl, D. E., Hanson, R. W., and Phelps, M. E., 1981, Ann. Neurology 10:173–183.CrossRefGoogle Scholar
  50. 49.
    Di Chiro, G., De La Paz, R., Smith, B., Kornblith, P., Sokoloff, L., Brooks, R., Blasberg, R., Cummins, C, Kessler, R., Wolf, A., Fowler, J., London, W., and Sever, J., 1981, J. Cerebral Blood Flow Metab. [Suppl.] 1:511–512.Google Scholar
  51. 50.
    Ackerman, R. H., Davis, S. M., Correia, J. A., Alpert, N. M., Buonanno, F., Finkelstein, S., Brownell, G. L., and Taveras, J. M., 1981, J. Cerebral Blood Flow Metab. [Suppl.] 1:5575–5576.Google Scholar
  52. 51.
    Bustany, P., Sargent, T., Saudubray, J. M., Henry, J. P., and Comar, D., 1981, J. Cerebral Blood Flow Metab. [Suppl.] 1:517–518.Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Jonathan D. Brodie
    • 1
  • Nora Volkow
    • 1
  • John Rotrosen
    • 2
  1. 1.Department of PsychiatryNew York University School of MedicineNew YorkUSA
  2. 2.Psychiatry ServiceVeterans Administration Medical CenterNew YorkUSA

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