Principles and Application of Positron Emission Tomography in Neuroscience

  • Jonathan D. Brodie
  • Nora Volkow
  • John Rotrosen


Positron Emission Tomography (PET) is a new nuclear medicine technique which evolved from the need to establish the relationship among the functional activity of the brain, its metabolic rate, and its anatomic structure. This technique allows the detection of the three-dimensional distribution within the brain of a previously administered positron-emitting radionuclide. Although similar in principle to quantitative autoradiography, it has the advantage of providing functional information of a structure in a living organism. Positron emission tomography incorporates principles from both transmission computed tomography and the uptake and flow techniques initially developed by Kety and Schmidt1 but has the advantage of being able to give information for localized regions of the brain. This information is based on the detection of the annihilation energy produced when a positron emitted from a radionuclide-labeled compound interacts with an electron in the tissue.


Positron Emission Tomography Cerebral Blood Flow Glucose Metabolism Visual Cortex Primary Visual Cortex 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Jonathan D. Brodie
    • 1
  • Nora Volkow
    • 1
  • John Rotrosen
    • 2
  1. 1.Department of PsychiatryNew York University School of MedicineNew YorkUSA
  2. 2.Psychiatry ServiceVeterans Administration Medical CenterNew YorkUSA

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