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Hyperfiltration as a Major Causative Factor in Initiation and Progression of Glomerulosclerosis

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Prevention of Kidney Disease and Long-Term Survival

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Abstract

The augmentation of single-nephron glomerular filtration rate (SNGFR) that follows loss of functioning renal mass is generally regarded as a beneficial adaptation in the sense that total filtration by the remnant kidney falls less than would be the case had this augmentation not occurred. However, several lines of evidence have been developed that, when taken together, suggest that single-nephron hyperfiltration may have maladaptive and eventually injurious consequences. For nearly 50 years it has been recognized that removal of approximately three fourths or more of the renal mass in the rat, either by surgical resection, infarction, or a combination of these maneuvers, results in a syndrome of progressive azotemia, proteinuria, and eventual glomerular sclerosis.l–3

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Author information

Authors and Affiliations

  1. Laboratory of Kidney and Electrolyte Physiology, Brigham and Women’s Hospital, Boston, Massachusetts, USA

    Thomas H. Hostetter

  2. Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA

    Helmut G. Rennke

  3. Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA

    Barry M. Brenner

  4. Renal Division, Brigham and Women’s Hospital, Boston, Massachusetts, USA

    Barry M. Brenner

Authors
  1. Thomas H. Hostetter
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  2. Helmut G. Rennke
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  3. Barry M. Brenner
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Editor information

Editors and Affiliations

  1. The Avram Center for Kidney Diseases, Division of Nephrology, The Long Island College Hospital, Brooklyn, New York, USA

    Morrell M. Avram M.D. (Chief, Clinical Professor of Medicine, Medical Director) (Chief, Clinical Professor of Medicine, Medical Director)

  2. Department of Medicine, Downstate Medical Center, Brooklyn, New York, USA

    Morrell M. Avram M.D. (Chief, Clinical Professor of Medicine, Medical Director) (Chief, Clinical Professor of Medicine, Medical Director)

  3. Brooklyn Kidney Center and Nephrology Foundation of Brooklyn, Brooklyn, New York, USA

    Morrell M. Avram M.D. (Chief, Clinical Professor of Medicine, Medical Director) (Chief, Clinical Professor of Medicine, Medical Director)

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© 1982 Plenum Publishing Corporation

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Hostetter, T.H., Rennke, H.G., Brenner, B.M. (1982). Hyperfiltration as a Major Causative Factor in Initiation and Progression of Glomerulosclerosis. In: Avram, M.M. (eds) Prevention of Kidney Disease and Long-Term Survival. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4199-4_5

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  • DOI: https://doi.org/10.1007/978-1-4684-4199-4_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4201-4

  • Online ISBN: 978-1-4684-4199-4

  • eBook Packages: Springer Book Archive

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