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Triggering Signals for T-Cell Activation in Renal Transplantation

  • Kurt H. Stenzel
  • A. L. Rubin
  • A. Novogrodsky

Abstract

Long-term survival of renal graft recipients and patients with immunologically mediated renal disease depends on the clarification of molecular mechanisms involved in T-cell activation. The lymphocyte membrane serves as a transmitter of external signals that induce cell proliferation and differentiation. The signals that interact with the cell membrane and trigger these events may be either immunologically specific, and induce a monoclonal proliferation, or immunologically nonspecific, and induce a polyclonal proliferation. Most T-cell mitogens, agents that induce polyclonal proliferation of T-cells, interact with cell surface polysaccharide moieties. These mitogens include certain lectins and the oxidizing agents sodium metaperiodate (IO4) and galactose oxidase (GO). The initial step in the triggering event is mitogen binding to, or alteration of, a cell surface saccharide structure. The nature of this interaction is central to the understanding of the molecular mechanisms responsible for lymphocyte activation, and the subsequent cascade of events that leads either to graft rejection or acceptance.

Keywords

Lymphocyte Activation TGase Activity Galactose Oxidase Membrane Site Soybean Agglutinin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1982

Authors and Affiliations

  • Kurt H. Stenzel
    • 1
  • A. L. Rubin
    • 1
  • A. Novogrodsky
    • 1
  1. 1.Rogosin Kidney CenterThe New York Hospital-Cornell Medical CenterNew YorkUSA

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