Over-Decade Maintenance Hemodialysis

Its Effect on Uremic Anemia and Coagulation
  • Frank W. Dipillo
  • Harsh Gandhi


Anemia is an almost invariable component of the uremic syndrome. The pathogenesis of uremic anemia has been related to: (1) failure of renal excretory function resulting in a metabolic and/or mechanical environment unfavorable to red cells; (2) subnormal red cell iron utilization; (3) decreased marrow responsiveness to erythropoietin; (4) the effect of impaired renal secretion of erythropoietin; (5) increased blood loss from ecchymoses, gastrointestinal, or gynecologic bleeding1,2; and (6) the erythropotoxic effect of excess parathyroid hormone, a common concomitant abnormality in uremia. The major factor in the genesis of uremic anemia appears to be a lack of renal erythropoietin stimulation of erythroid marrow.3–5 The Long Island College Hospital group has, for more than a decade, implicated the possible role of parathyroid hormone (PTH) as a uremic toxin.6,7


Chronic Myelogenous Leukemia Partial Thromboplastin Time Uremic Patient Uremic Toxin Fibrin Degradation Product 
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Copyright information

© Plenum Publishing Corporation 1982

Authors and Affiliations

  • Frank W. Dipillo
    • 1
  • Harsh Gandhi
    • 1
  1. 1.Division of Hematology/OncologyThe Long Island College HospitalBrooklynUSA

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