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Immunopathologic Disease of the Central Nervous System

  • Michael B. A. Oldstone
Part of the Current Topics in Neurobiology book series (CTNB)

Abstract

Several of the chapters in this book are concerned with the definition of antigens specific to the nervous system. Such antigens promise to be of great importance for future investigations in a variety of contexts in cellular neurobiology. An important aspect of neuroimmunology that such studies do not consider is that of the immunopathologic mechanisms operating when these and other antigens in the nervous system provoke an immune response. In the peripheral nervous system, one of the most important examples is that of the response to the acetylcholine receptor underlying experimental and human myasthenic syndromes (see Chapter 1).

Keywords

Systemic Lupus Erythematosus Immune Complex Myelin Basic Protein Choroid Plexus Experimental Allergic Encephalomyelitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bluestein, H. G., Williams, G. W., and Steinberg, A. D., 1981, Cerebrospinal fluid antibodies to neuronal cells: Association with neuropsychiatric manifestations of systemic lupus erythematosus, Amer. J. Med. 70:241.CrossRefGoogle Scholar
  2. Cooper, N. R., 1980, The complement system, in: Basic and Clinical Immunology, 3rd ed. (H. H. Fudenberg, D. P. Stites, J. L. Caldwell, and J. V. Wells, eds.), pp. 83–95, Lang Medical Publishers, Palo Alto, Calif.Google Scholar
  3. Erlich, P., 1885, Das Sauerstaff-Bedürfniss des Organesmus, August Hiorchwald, Berlin.Google Scholar
  4. Harbeck, R. J., Hoffman, A. A., Hoffman, S. A., and Shucard, D. W., 1979, Cerebrospinal fluid and the choroid plexus during acute immune complex disease. Clin. Immunol. Immunopathol. 13:413.PubMedCrossRefGoogle Scholar
  5. Hugli, T. E., 1981, The structural basis for anaphylatoxin and chemotactic functions of C3a, C4a, and C5a, Critical Reviews in Immunology 1:321.PubMedGoogle Scholar
  6. Husby, G., Van de Rijn, I., Zabriskie, J. B., Abdin, Z. H., and Williams, Jr., R. C., 1976, Antibodies reacting with cytoplasm of subthalamic and caudate nuclei neurons in chorea and acute rheumatic fever, J. Exp. Med. 144:1094.PubMedCrossRefGoogle Scholar
  7. Jankovic, B. D., Draskoci, M., and Janjic, M., 1965, Passive transfer of “allergic” encephalomyelitis with antibrain serum injected into the lateral ventricle of the brain, Nature (London) 207:428.CrossRefGoogle Scholar
  8. Kabat, E. A., Wolf, A., and Bezer, A. E., 1949, Studies on acute disseminated encephalomyelitis produced experimentally in Rhesus monkeys. IV. Disseminated encephalomyelitis produced in monkeys with their own brain tissue, J. Exp. Med. 89:395.PubMedCrossRefGoogle Scholar
  9. Lampert, P. W., and Oldstone, M. B. A., 1973, Host IgG and C3 deposits in the choroid plexus during spontaneous immune complex disease, Science 180:408.PubMedCrossRefGoogle Scholar
  10. Lennon, V. A., and Carnegie, P. R., 1971, Immunopharmacological disease: A break in tolerance to receptor sites, Lancet 1:630.PubMedCrossRefGoogle Scholar
  11. Morgan, I. M., 1947, Allergic encephalomyelitis in monkeys in response to injection of normal monkey nervous tissue, J. Exp. Med. 85:131.PubMedCrossRefGoogle Scholar
  12. Müller-Eberhard, H. J., 1975, Complement, Annu. Rev. Biochem. 44:697.PubMedCrossRefGoogle Scholar
  13. Müller-Eberhard, H. J., and Schreiber, R. D., 1980, Molecular biology and chemistry of the alternative pathway of complement, Adv. Immunol. 29:1.PubMedCrossRefGoogle Scholar
  14. Norrby, E., Link, H., Olsson, J-E., Panelius, M., Salmi, A., and Vandvik, B., 1974, Comparison of antibodies against different viruses in cerebrospinal fluid and serum samples from patients with multiple sclerosis, Infect. Immun. 10:688.PubMedGoogle Scholar
  15. Oldstone, M. B. A., 1975, Virus neutralization and virus-induced immune complex disease: Virus-antibody union resulting in immunoprotection or immunologic injury—Two different sides of the same coin, in: Progress in Medical Virology, Vol. 19 (J. L. Melnick, ed.), pp. 84–119, S. Karger, Basel.Google Scholar
  16. Oldstone, M. B. A., and Dixon, F. J., 1970, Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. II. Relationship of anti-LCM viral response to tissue injury in chronic disease, J. Exp. Med. 131:1.PubMedCrossRefGoogle Scholar
  17. Oldstone, M. B. A., and Lampert, P. W., 1974, Immune complex disease in chronic virus infection: Involvement of the choroid plexus, in: Advances in the Biosciences, vol. 12 (G. Raspe and S. Bernhard, eds.), pp.. 381–390, Pergamon Press, London.Google Scholar
  18. Ortiz-Ortiz, L., and Weigle, W. O., 1976, Cellular events in the induction of experimental allergic encephalomyelitis in rats, J. Exp. Med. 144:604.PubMedCrossRefGoogle Scholar
  19. Paterson, P. Y., 1966, Experimental allergic encephalomyelitis and autoimmune diseases, Adv. Immunol. 5:131.PubMedCrossRefGoogle Scholar
  20. Paterson, P. Y., 1977, Autoimmune neurological disease: Experimental animal systems and implications for multiple sclerosis, in: Autoimmunity: Genetic, Immunologic, Virologic, and Clinical Aspects (N. Talal, ed.), pp. 643–692, Academic Press, New York.Google Scholar
  21. Perlmann, P., and Cerottini, J. C., 1979, Cytotoxic lymphocytes, in: The Antigens, vol. 5 (M. Sela, ed.), pp. 173–281, Academic Press, New York.Google Scholar
  22. Petz, L. D., Sharp, G. C., Cooper, N. R., and Irvin, W. S., 1971, Serum and cerebral spinal fluid complement and serum autoantibodies in systemic lupus erythematosus, Medicine 50:259.PubMedCrossRefGoogle Scholar
  23. Rivers, T. M., and Schwentker, F. F., 1935, Encephalomyelitis accompanied by myelin destruction experimentally produced in monkeys, J. Exp. Med. 61:689.PubMedCrossRefGoogle Scholar
  24. Saida, K., Saida, T., Brown, M. J., and Silberberg, D. H., 1979, In vivo demyelination induced by intraneural injection of anti-galactocerebroside serum. A morphologic study, Am. J. Pathol. 95:99.PubMedGoogle Scholar
  25. Simon, J., and Simon, O., 1975, Effect of passive transfer of anti-brain antibodies to a normal recipient, Exp. Neurol. 47(3):523.PubMedCrossRefGoogle Scholar
  26. Sissons, J. G. P., and Oldstone, M. B. A., 1980, Antibody-mediated destruction of virus-infected cells, Adv. Immunol. 29:209.PubMedCrossRefGoogle Scholar
  27. Tourtellotte, W. W., 1972, Interaction of local central nervous system immunity and systemic immunity in the spread of multiple sclerosis demyelination, in: Multiple Sclerosis (F. Wolfgram, G. W. Ellison, J. G. Stevens, and J. M. Andrews, eds.), p. 285, Academic Press, New York.Google Scholar
  28. Welsh, R. M., Jr., 1978, Mouse natural killer cells: Induction, specificity, and function, J. Immunol. 121:1631.PubMedGoogle Scholar
  29. Werdelin, O., and McCluskey, R. T., 1971, The nature and the specificity of mononuclear cells in experimental autoimmune inflammations and the mechanisms leading to their accumulation, J. Exp. Med. 133:1242.PubMedCrossRefGoogle Scholar
  30. Zinkernagel, R. M., and Doherty, P. C., 1979, MHC restricted cytotoxic T cells: Studies on the biological role of polymorphic major transplantation antigens determining T cell restriction, specificity, function and responsiveness, Adv. Immunol. 27:52.Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Michael B. A. Oldstone
    • 1
  1. 1.Department of ImmunopathologyScripps Clinic and Research FoundationLa JollaUSA

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