Monoclonal Antibodies to Skeletal Muscle Cell Surface

  • Douglas M. Fambrough
  • Ellen K. Bayne
  • John M. Gardner
  • M. John Anderson
  • Eric Wakshull
  • Richard L. Rotundo
Part of the Current Topics in Neurobiology book series (CTNB)


About half of the mass of a vertebrate’s body is muscle tissue, of which the principal cell is the muscle fiber: an extremely long, multinucleate cell which has a regionally specialized surface for interaction with tendons, for propagation of action potentials, and for reception of chemical signals from motor neurons. The intimate relation between motor neuron and muscle fiber has been of special importance to neurobiologists. Studies of the neuromuscular junction have provided fundamental information about synaptic communication. Furthermore, evidence of long-term trophic interactions between muscle fibers and motor neurons has been important for the development of ideas about the plasticity and stability of neuronal connections.


Acetylcholine Receptor Basal Lamina Neuromuscular Junction Plasma Membrane Protein Myogenic Cell 


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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Douglas M. Fambrough
    • 1
  • Ellen K. Bayne
  • John M. Gardner
  • M. John Anderson
  • Eric Wakshull
  • Richard L. Rotundo
  1. 1.Department of EmbryologyCarnegie Institution of WashingtonBaltimoreUSA

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