Monoclonal Antibodies to Skeletal Muscle Cell Surface
About half of the mass of a vertebrate’s body is muscle tissue, of which the principal cell is the muscle fiber: an extremely long, multinucleate cell which has a regionally specialized surface for interaction with tendons, for propagation of action potentials, and for reception of chemical signals from motor neurons. The intimate relation between motor neuron and muscle fiber has been of special importance to neurobiologists. Studies of the neuromuscular junction have provided fundamental information about synaptic communication. Furthermore, evidence of long-term trophic interactions between muscle fibers and motor neurons has been important for the development of ideas about the plasticity and stability of neuronal connections.
KeywordsAcetylcholine Receptor Basal Lamina Neuromuscular Junction Plasma Membrane Protein Myogenic Cell
Unable to display preview. Download preview PDF.
- Berg, D. K., and Hall, Z. W., 1975, Loss of α-bungarotoxin from junctional and extrajunctional acetylcholine receptors in rat diaphragm in vivo and in organ culture, J. Physiol. (London) 252:771.Google Scholar
- Fambrough, D. M., Devreotes, P. N., Card, D. J., Gardner, J., and Tepperman, K., 1978, Metabolism of acetylcholine receptors in skeletal muscle, Natl. Cancer Inst. 48:277.Google Scholar
- Lomo, T., and Westgaard, R. H., 1975, Further studies on the control of ACh sensitivity by muscle activity in the rat, J. Physiol. (London) 252:603.Google Scholar
- Rotundo, R. L., Gardner, J. M., Bayne, E. K., Wakshull, E., Anderson, M. J., and Fambrough, D. M., 1980, Cell surface and secretory glycoproteins of skeletal muscle, Carnegie Inst. Washington Yearb. 79:19.Google Scholar