Immunology of the Neuromuscular Junction

  • Regis B. Kelly
  • Zach W. Hall
Part of the Current Topics in Neurobiology book series (CTNB)


Although the vertebrate neuromuscular junction has surely been the most intensively studied synapse in the nervous system, we know remarkably little about its structure and function at a molecular level. One simple reason for this is that the junction forms only a miniscule part of the total muscle tissue, and methods have not been devised for its purification as an intact structure. Isolation of any molecular component of the synapse is thus a formidable task. The only protein that has been extensively purified from the neuromuscular junction is the acetylcholine receptor (AChR); even in this case, the small amount of protein that can be obtained limits severely the kinds of experiments that can be done.


Acetylcholine Receptor Synaptic Vesicle Neuromuscular Junction Synaptic Cleft Choline Acetyltransferase 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Regis B. Kelly
    • 1
  • Zach W. Hall
    • 2
  1. 1.Department of Biochemistry and BiophysicsUniversity of CaliforniaSan FranciscoUSA
  2. 2.Division of Neurobiology, Department of PhysiologyUniversity of CaliforniaSan FranciscoUSA

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