Stimulated Phosphatidylinositol Turnover A Brief Appraisal

  • R. F. Irvine
  • R. M. C. Dawson
  • N. Freinkel


The phospholipid phosphatidylinositol (Fig. 1) (PI) is ubiquitous in animal tissues and occurs as a minor component (10 ± 5%; White, 1973) of the lipid bilayer of their cellular membranes. Its chemical structure is illustrated in Fig. 1, and the ester bonds that the various phospholipases can cleave are indicated. It is our intention in this introduction to review only briefly the history of the study of PI turnover and its relationship to cell stimulation, as detailed accounts can be found in reviews by L. E. Hokin (1968), Hawthorne and White (1975), and Michell (1975).


Arachidonic Acid Phosphatidic Acid Arachidonic Acid Release Acyl Transfer Diacylglycerol Lipase 


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Copyright information

© Plenum Publishing Corporation 1982

Authors and Affiliations

  • R. F. Irvine
    • 1
  • R. M. C. Dawson
    • 1
  • N. Freinkel
    • 2
  1. 1.Department of BiochemistryAgricultural Research Council Institute of Animal PhysiologyBabrahamEngland
  2. 2.Center for Endocrinology, Metabolism, and Nutrition and Departments of Medicine and BiochemistryNorthwestern University Medical SchoolChicagoUSA

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